Abstract
1 Phenelzine cannot be extracted as such from biological fluids.
2 Formation of the acetonide derivative prior to extraction allows phenelzine to be extracted and assayed by gas chromatography at levels down to 0.5 μg/ml.
3 At this sensitivity the drug can be detected in urine but not in plasma, after therapeutic doses.
4 Persons typed as slow acetylators of sulphadimidine excreted approximately twice as much unmetabolized phenelzine in urine compared to fast acetylators.
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Selected References
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