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. 1976 Aug;3(4):523–531. doi: 10.1111/j.1365-2125.1976.tb04871.x

An electroencephalographic investigation of short-term effects of three hypothalamic hormones (trh, lh/fsh-rh, gh-rih) in normal subjects

Heather Ashton, J E Millman, Rosemary Telford, J W Thompson, T F Davies, R Hall
PMCID: PMC1428921  PMID: 22216490

Abstract

1 Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects.

2 TRH was given as a 10 ml infusion of 600 μg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude.

3 LH/FSH-RH was given in a dose of 200 μg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects.

4 GH-RIH was given as a 10 ml infusion of 250 μg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.

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Selected References

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