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. 1976 Oct;3(5):891–895. doi: 10.1111/j.1365-2125.1976.tb00643.x

Serum and lung tissue levels of cephradine in thoracic surgery.

I J Kiss, E Faragó, J Pintér
PMCID: PMC1428944  PMID: 973983

Abstract

Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar-diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post-operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic-surgical infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailey A., Walker A., Hadley A., James D. G. Cephalexin--a new oral antibiotic. Practitioner. 1970 Dec;205(230):791–795. [PubMed] [Google Scholar]
  2. Berté F., De Bernardi M., Manzo L., Benzi G. Tissue distribution of cephalexin in pregnant rabbit and fetus after oral and intramuscular administration. Chemotherapy. 1972;17(5):344–347. doi: 10.1159/000220866. [DOI] [PubMed] [Google Scholar]
  3. Biró L., Graber H., Iván E. Kísérletes vizsgálatok cephaloridinnel. Orv Hetil. 1966 Nov 27;107(48):2264–2268. [PubMed] [Google Scholar]
  4. Eyckmans L., Van Landuyt H., Verberckmoes R. Clinical evaluation of cephaloglycin in the treatment of urinary tract infections. Chemotherapy. 1968;13(4):193–203. doi: 10.1159/000220549. [DOI] [PubMed] [Google Scholar]
  5. Harvengt C., De Schepper P., Lamy F., Hansen J. Cephradine absorption and excretion in fasting and nonfasting volunteers. J Clin Pharmacol New Drugs. 1973 Jan;13(1):36–40. doi: 10.1002/j.1552-4604.1973.tb00066.x. [DOI] [PubMed] [Google Scholar]
  6. Holloway W. J. The use of oral penicillins and cephalosporins in the treatment of urinary tract infections. Int J Clin Pharmacol. 1972 Apr;6(1):1–6. [PubMed] [Google Scholar]
  7. Irmer W., Lubach D., Sucker U. Cepalexinbestimmungen in Serum, Urin, Galle, Peritonealexsudat und Knochenmark. Dtsch Med Wochenschr. 1971 Mar 12;96(11):464–468. doi: 10.1055/s-0028-1108274. [DOI] [PubMed] [Google Scholar]
  8. Kiss J. I., Faragó E., Kónya L., Fábián E., Móricz F. Clinico-pharmacological examination of gentamycin in thoracic surgery. Int J Clin Pharmacol Biopharm. 1975 Oct;12(3):372–380. [PubMed] [Google Scholar]
  9. Kiss J., Faragó E., Fábián E+FABIAN E. Study of oxacillin levels in human serum and lung tissue. Ther Hung. 1974;22(2):55–59. [PubMed] [Google Scholar]
  10. Kiss J., Pintér J., Faragó E., Móricz F. Untersuchung der Meticillinkonzentration im Serum und im Lungengewebe beim Menschen. Acta Chir Acad Sci Hung. 1974;15(4):375–382. [PubMed] [Google Scholar]
  11. Klastersky J., Daneau D., Weerts D. Cephradine. Antibacterial activity and clinical effectiveness. Chemotherapy. 1973;18(3):191–204. doi: 10.1159/000221261. [DOI] [PubMed] [Google Scholar]
  12. Nelson J. D. Antibiotic concentrations in septic joint effusions. N Engl J Med. 1971 Feb 18;284(7):349–353. doi: 10.1056/NEJM197102182840702. [DOI] [PubMed] [Google Scholar]

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