Abstract
We investigated the effects of oral aspirin 900 mg upon the platelet aggregation responses to 5-hydroxytryptamine, dopamine or N-dimethyl dopamine in schizophrenic patients chronically treated with chlorpromazine. Most subjects showed enchanced aggregation responses (that is appearance of secondary phase aggregation) to these agents prior to aspirin administration. When aggregation was re-tested 23.5 h after aspirin the secondary phase of the enhanced aggregation responses was abolished. Addition of 0.14-0.3 mumol/l prostaglandin E2 15 s after inducing aggregation partially restored the secondary phase. The observed secondary phase of aggregation may be due to increased prostaglandin synthesis or release.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boullin D. J., Woods H. F., Grimes R. P., Grahame-Smith D. G. Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine. Br J Clin Pharmacol. 1975 Feb;2(1):29–35. doi: 10.1111/j.1365-2125.1975.tb00468.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Brien J. R., Finch W., Clark E. A comparison of an effect of different anti-inflammatory drugs on human platelets. J Clin Pathol. 1970 Sep;23(6):522–525. doi: 10.1136/jcp.23.6.522. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shio H., Ramwell P. Effect of prostaglandin E 2 and aspirin on the secondary aggregation of human platelets. Nat New Biol. 1972 Mar 15;236(63):45–46. doi: 10.1038/newbio236045a0. [DOI] [PubMed] [Google Scholar]
- Weiss H. J. Platelet physiology and abnormalities of platelet function (first of two parts). N Engl J Med. 1975 Sep 11;293(11):531–541. doi: 10.1056/NEJM197509112931105. [DOI] [PubMed] [Google Scholar]