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. 1976 Dec;3(6):1001–1005. doi: 10.1111/j.1365-2125.1976.tb00349.x

Adrenoceptor responsiveness in bronchial asthma

Effect of isoprenaline inhalation on plasma cyclic 3′,5′-amp levels

P W Trembath, J Shaw
PMCID: PMC1428971  PMID: 22216521

Abstract

1 The effect of isoprenaline inhalation on plasma levels of cyclic AMP has been studied in a group of normal subjects and compared to a group of asthmatics.

2 The normal subjects had a prompt rise in their plasma cyclic AMP level, and when compared to the asthmatic group, had a significantly greater percentage rise in plasma cyclic AMP from the basal levels.

3 The markedly attenuated response to isoprenaline inhalation in the asthmatic group is consistent with the concept that asthmatics have a relative impairment of β-adrenoceptor function.

4 These results support the in vitro studies demonstrating that lymphocytes from asthmatic subjects incubated with isoprenaline produce less cyclic AMP than those from normal subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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