Abstract
1. The acute haemodynamic effects of metoprolol (0.15 mg/kg body weight) intravenously were studied at rest and during exercise, in a recumbent position in five patients with arterial hypertension of WHO Stage 1 or 2. 2. Significant decreases in heart rate, cardiac output and arterial blood pressures, both at rest and during exercise, were seen. There were no changes in the calculated stroke volume or systemic vascular resistance. 3. The apparent absence of any relative preponderance of the alpha-adrenoreceptors after acute beta-adrenoreceptor blockade with metoprolol warrants further studies on metoprolol in arterial hypertension.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ablad B., Borg K. O., Carlsson E., EK L., Johnson G., Malmfors T., Regårdh C. G. A survey of the pharmacological properties of metoprolol in animals and man. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):7–23. doi: 10.1111/j.1600-0773.1975.tb03318.x. [DOI] [PubMed] [Google Scholar]
- Johnsson G. Influence of metoprolol and propranolol on hemodynamic effects induced by adrenaline and physical work. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):59–68. doi: 10.1111/j.1600-0773.1975.tb03322.x. [DOI] [PubMed] [Google Scholar]
- Sannerstedt R., Julius S., Conway J. Hemodynamic responses to tilt and beta-adrenergic blockade in young patients with borderline hypertension. Circulation. 1970 Dec;42(6):1057–1064. doi: 10.1161/01.cir.42.6.1057. [DOI] [PubMed] [Google Scholar]
- Stenberg J., Wasir H., Amery A., Sannerstedt R., Werkö L. Comparative hemodynamic studies in man of adrenergic bepta-1-receptors agents without (h 93/26 equal to metoprolol) or with (h 87/07) intrinsic sympathicomimetic activity. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):76–84. doi: 10.1111/j.1600-0773.1975.tb03324.x. [DOI] [PubMed] [Google Scholar]