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. 1977 Apr;4(2):157–162. doi: 10.1111/j.1365-2125.1977.tb00688.x

Effects of labetalol and propranolol on histamine-induced bronchoconstriction in normal subjects.

J G Maconochie, E P Woodings, D A Richards
PMCID: PMC1429018  PMID: 861131

Abstract

1 The effects of oral propranolol (80 mg), labetalol (400 mg) and placebo on blood pressure, pulse rate and FEV1 at rest and after inhaled histamine, have been compared in six healthy male volunteers. 2 At 90 and 120 min after ingestion propranolol reduced the pulse rate and labetalol reduced the blood pressure, thus confirming absorption of each drug. 3 At 120 min propranolol reduced resting FEV1 and enhanced the fall in FEV1 after histamine, whereas the alterations in FEV1 after labetalol did not differ from placebo. 4 These findings suggest that labetalol is less likely than propranolol to cause bronchoconstriction in asthmatic patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablad B., Borg K. O., Carlsson E., EK L., Johnson G., Malmfors T., Regårdh C. G. A survey of the pharmacological properties of metoprolol in animals and man. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):7–23. doi: 10.1111/j.1600-0773.1975.tb03318.x. [DOI] [PubMed] [Google Scholar]
  2. Aellig W. H. beta-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers. Br J Clin Pharmacol. 1976 Apr;3(2):251–257. doi: 10.1111/j.1365-2125.1976.tb00600.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anthracite R. F., Vachon L., Knapp P. H. Alpha-adrenergic receptors in the human lung. Psychosom Med. 1971 Nov-Dec;33(6):481–489. doi: 10.1097/00006842-197111000-00001. [DOI] [PubMed] [Google Scholar]
  4. Bianco S., Griffin J. P., Kamburoff P. L., Prime F. J. Prevention of exercise-induced asthma by indoramin. Br Med J. 1974 Oct 5;4(5935):18–20. doi: 10.1136/bmj.4.5935.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Farmer J. B., Kennedy I., Levy G. P., Marshall R. J. Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors. Br J Pharmacol. 1972 Aug;45(4):660–675. doi: 10.1111/j.1476-5381.1972.tb08125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Griffin J. P., Turner P. Preliminary studies of a new bronchodilator (WG 253) in man. J Clin Pharmacol New Drugs. 1971 Jul-Aug;11(4):280–287. [PubMed] [Google Scholar]
  7. Kumana C. R., Marlin G. E., Kaye C. M., Smith D. M. New approach to assessment of cardioselectivity of beta-blocking drugs. Br Med J. 1974 Nov 23;4(5942):444–447. doi: 10.1136/bmj.4.5942.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MCNEILL R. S. EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS. Lancet. 1964 Nov 21;2(7369):1101–1102. doi: 10.1016/s0140-6736(64)92617-0. [DOI] [PubMed] [Google Scholar]
  9. Macdonald A. G., McNeill R. S. A comparison of the effect on airway resistance of a new beta blocking drug, ICI.50,172 and propranolol. Br J Anaesth. 1968 Jul;40(7):508–510. doi: 10.1093/bja/40.7.508. [DOI] [PubMed] [Google Scholar]
  10. Richards D. A. Pharmacological effects of labetalol in man. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):721–723. [PubMed] [Google Scholar]
  11. Richards D. A., Tuckman J., Prichard B. N. Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol. Br J Clin Pharmacol. 1976 Oct;3(5):849–855. doi: 10.1111/j.1365-2125.1976.tb00637.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Skinner C., Gaddie J., Palmer K. N. Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59–61. doi: 10.1136/bmj.2.5962.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Skinner C., Palmer K. N. Comparison of the effects of acebutolol (Sectral) and practolol (Eraldin) on airways obstruction in asthmatics. Br J Clin Pharmacol. 1975 Oct;2(5):417–422. doi: 10.1111/j.1365-2125.1975.tb00550.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. TOWNLEY R. G., DENNIS M., ITKIN I. H. COMPARATIVE ACTION ON ACETYL-BETA-METHYLCHOLINE, HISTAMINE, AND POLLEN ANTIGENS IN SUBJECTS WITH HAY FEVER AND PATIENTS WITH BRONCHIAL ASTHMA. J Allergy. 1965 Mar-Apr;36:121–137. doi: 10.1016/0021-8707(65)90161-9. [DOI] [PubMed] [Google Scholar]
  15. Zaid G., Beall G. N. Bronchial response to beta-adrenergic blockade. N Engl J Med. 1966 Sep 15;275(11):580–584. doi: 10.1056/NEJM196609152751103. [DOI] [PubMed] [Google Scholar]

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