Abstract
A double-blind, placebo controlled, crossover trial of 20 and 40 mg of xipamid once daily in the treatment of mild to moderate hypertension is reported and some of the difficulties and pitfalls of multicentre trials of this type are described. 2 Both doses were significantly more effective in reducing the blood pressure than the placebo and neither was superior to the other. Both produced some potassium loss. Xipamid acted for at least 22 h and was effective in up to 83% of the patients. 3 Further trials are suggested to investigate the activity of a lower dose than 20 mg.
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Selected References
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- Kalos A., Dixon A. S., Weber J. C. Xipamid in the treatment of oedema in rheumatoid arthritis. Rheumatol Rehabil. 1974 May;13(2):81–87. doi: 10.1093/rheumatology/13.2.81. [DOI] [PubMed] [Google Scholar]
- Piyasena K. H., Havard C. W., Weber J. C. Xipamid, a potent new diuretic. Curr Med Res Opin. 1975;3(3):121–125. doi: 10.1185/03007997509113658. [DOI] [PubMed] [Google Scholar]