Abstract
1 Nomifensine is a new substance which showed, in tests for antidepressant activity, a pronounced effect which is quantitatively better than that of the reference substances.
2 With regard to thymoleptic effects in animal studies the effect of nomifensine is similar to that of tricyclic antidepressants, but nomifensine has no pronounced anticholinergic activity.
3 Nomifensine influences the cardiovascular system very slightly.
4 The mechanism of action of nomifensine differs from that of tricyclic antidepressants and must be clearly differentiated from phenylalkyl amines with sympathomimetic activity.
5 Nomifensine is a compound with a special, new profile of action, and thus cannot be classified in known categories.
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Selected References
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