Abstract
1 Six healthy volunteers received single doses of either nomifensine 100 mg, nomifensine 50 mg or placebo at weekly intervals in a randomized double-blind crossover study.
2 Subjects were subjected to a simulated test of car driving at night.
3 Testing lasted about 1.5 h and consisted of measuring responses to light stimuli, a modification of a test designed by Baker & Theologus (1972).
4 Nomifensine 100 mg reduced the latency of response significantly when compared with placebo (P<0.05). Nomifensine 50 mg had no significant effect.
5 It was concluded that nomifensine was unlikely to impair night driving performance.
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Selected References
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