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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1977;4(Suppl 2):117S–121S. doi: 10.1111/j.1365-2125.1977.tb05737.x

A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques

J Chamberlain, H M Hill
PMCID: PMC1429139  PMID: 911647

Abstract

1 A rapid simple gas chromatographic technique for determining nomifensine in plasma is described.

2 Nomifensine is rapidly absorbed after oral administration to man.

3 Following a 100-mg dose, peak levels of an acid-labile conjugate of 2—3 μg/ml are reached about 1.5 h after administration.

4 The conjugate is cleared with a half-life of between 1 and 2 hours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailey E., Fenoughty M., Richardson L. Automated high-resolution gas chromatographic analysis of psychotropic drugs in biological fluids using open-tubular glass capillary columns. I. Determination of nomifensine in human plasma. J Chromatogr. 1977 Jan 21;131:347–355. doi: 10.1016/s0021-9673(00)80951-6. [DOI] [PubMed] [Google Scholar]
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