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. 1977 Oct;4(5):591–595. doi: 10.1111/j.1365-2125.1977.tb00791.x

Hydroxyethyl starch. An agent for hypovolaemic schock treatment II. Urinary excretion in normal volunteers following three consecutive daily infusions.

J M Mishler, H Borberg, P M Emerson, R Gross
PMCID: PMC1429164  PMID: 71913

Abstract

1 Urinary hydroxyethyl starch (HES) concentrations were determined by the anthrone method, in four healthy normal male volunteers following three consecutive daily 500 ml infusions (total 1500 ml), in order to ascertain excretion rates under normal controlled conditions. 2 The HES was excreted at a rate of 2.57, 2.46, and 2.44 g/h during the first hour postinjection, on days 1, 2, and 3, respectively. 3 The rate during the interval 12-24 h postinjection, averaged 0.14, 0.21, and 0.10 g/h, on days 1,2, and 3, respectively. 4 In the intervals 24-72, 72-120, and 120-168 h after the third and final injection, the excretion rate was 0.07, 0.04, and 0.02 g/h, respectively. 5 Renal function, as assessed by serum creatinine and uric acid concentrations and 24 h void volumes, was normal during the entire period of observation. 6 The results indicate that HES is excreted at a similar rate following three consecutive daily infusions without evidence of renal injury.

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Selected References

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  1. Ballinger W. F., 2nd, Murray G. F., Morse E. E. Preliminary report on the use of hydroxyethyl starch solution in man. J Surg Res. 1966 Apr;6(4):180–183. doi: 10.1016/s0022-4804(66)80014-8. [DOI] [PubMed] [Google Scholar]
  2. Ballinger W. F., 2nd, Solanke T. F., Thompson W. L. The effect of hydroxyethyl starch upon survival of dogs subjected to hemorrhagic shock. Surg Gynecol Obstet. 1966 Jan;122(1):33–36. [PubMed] [Google Scholar]
  3. Dillon J., Lynch L. J., Jr, Myers R., Butcher H. R., Jr, Moyer C. A. A bioassay of treatment of hemorrhagic shock. I. The roles of blood, Ringer's solution with lactate, and macromolecules (dextran and hydroxyethyl starch) in the treatment of hemorrhagic shock in the anesthetized dog. Arch Surg. 1966 Oct;93(4):537–555. doi: 10.1001/archsurg.1966.01330040001001. [DOI] [PubMed] [Google Scholar]
  4. Evangelista B. S., Green T. J., Gwilt D. J., Brown T. G., Jr An experimental study of current therapeutic approaches to endotoxin shock. Arch Int Pharmacodyn Ther. 1969 Jul;180(1):57–67. [PubMed] [Google Scholar]
  5. Farrow S. P., Hall M., Ricketts C. R. Changes in the molecular composition of circulating hydroxyethyl starch. Br J Pharmacol. 1970 Apr;38(4):725–730. doi: 10.1111/j.1476-5381.1970.tb09880.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gollub S., Schechter D. C., Hirose T., Bailey C. P. Use of hydroxyethyl starch solution in extensive surgical operations. Surg Gynecol Obstet. 1969 Apr;128(4):725–728. [PubMed] [Google Scholar]
  7. Gollub S., Vanichanan C., Schaefer C., Schechter D. C. A study of safer plasma substitutes. Surg Gynecol Obstet. 1969 Jun;128(6):1235–1243. [PubMed] [Google Scholar]
  8. Lee W. H., Jr, Cooper N., Weidner M. G., Jr, Murner E. S. Clinical evaluation of a new plasma expander hydroxyethyl starch. J Trauma. 1968 May;8(3):381–393. doi: 10.1097/00005373-196805000-00005. [DOI] [PubMed] [Google Scholar]
  9. MURPHY G. P., DEMAREE D. E., GAGNON J. A. THE RENAL AND SYSTEMIC EFFECTS OF HYDROXYETHYL STARCH SOLUTION INFUSIONS. J Urol. 1965 May;93:534–539. doi: 10.1016/S0022-5347(17)63822-9. [DOI] [PubMed] [Google Scholar]
  10. Metcalf W., Papadopoulos A., Tufaro R., Barth A. A clinical physiologic study of hydroxyethyl starch. Surg Gynecol Obstet. 1970 Aug;131(2):255–267. [PubMed] [Google Scholar]
  11. Murphy G. P. The renal effects of acute hemodilution with hydroxyethyl starch, dextran, or saline. Surg Gynecol Obstet. 1965 Dec;121(6):1325–1333. [PubMed] [Google Scholar]
  12. Murray G. F., Solanke T., Thompson W. L., Ballinger W. F. Hydroxyethyl starch as a plasma expander in hemorrhagic shock. Surg Forum. 1965;16:34–35. [PubMed] [Google Scholar]
  13. Silk M. R. The effect of dextran and hydroxyethyl starch on renal hemodynamics. J Trauma. 1966 Nov;6(6):717–723. doi: 10.1097/00005373-196611000-00003. [DOI] [PubMed] [Google Scholar]
  14. Solanke T. F. Clinical trial of 6 per cent hydroxyethyl starch (a new plasma expander). Br Med J. 1968 Sep 28;3(5621):783–785. doi: 10.1136/bmj.3.5621.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. THOMPSON W. L., BRITTON J. J., WALTON R. P. Persistence of starch derivatives and dextran when infused after hemorrhage. J Pharmacol Exp Ther. 1962 Apr;136:125–132. [PubMed] [Google Scholar]
  16. Takaori M., Safar P., Galla S. J. Comparison of hydroxyethyl starch with plasma and dextrans in severe haemodilution. Can Anaesth Soc J. 1968 Jul;15(4):347–356. doi: 10.1007/BF03006959. [DOI] [PubMed] [Google Scholar]
  17. Thompson W. L., Fukushima T., Rutherford R. B., Walton R. P. Intravascular persistence, tissue storage, and excretion of hydroxyethyl starch. Surg Gynecol Obstet. 1970 Nov;131(5):965–972. [PubMed] [Google Scholar]

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