Abstract
1 There is evidence that erythrocyte Na+-K+-ATPase activity and erythrocyte cyclic AMP change on recovery from a depressive illness. Mianserin is a recently introduced antidepressant but its mode of action is unknown. The present study was therefore designed to investigate in vivo the effect of mianserin on erythrocyte Na+-K+-ATPase and cyclic AMP.
2 Biochemical estimations were made on blood from depressed patients before beginning either mianserin or matched placebo treatment, after 1 week, and again after 2 weeks' treatment.
3 Neither the erythrocyte Na+-K+-ATPase, nor the erythrocyte cyclic AMP concentration, changed significantly in either the mianserin- or the placebo-treated group.
4 The study sheds no light on the possible mechanism of action of mianserin.
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Selected References
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- Abdulla Y. H., Hamadah K. 3',5' cyclic adenosine monophosphate in depression and mania. Lancet. 1970 Feb 21;1(7643):378–381. doi: 10.1016/s0140-6736(70)91514-x. [DOI] [PubMed] [Google Scholar]
- Brown B. L., Albano J. D., Ekins R. P., Sgherzi A. M. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. Biochem J. 1971 Feb;121(3):561–562. doi: 10.1042/bj1210561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COPPEN A. J. Abnormality of the blood-cerebrospinal fluid barrier of patients suffering from a depressive illness. J Neurol Neurosurg Psychiatry. 1960 May;23:156–161. doi: 10.1136/jnnp.23.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glen A. I., Ongley G. C., Robinson K. Diminished membrane transport in manic-depressive psychosis and recurrent depression. Lancet. 1968 Aug 3;2(7562):241–243. doi: 10.1016/s0140-6736(68)92351-9. [DOI] [PubMed] [Google Scholar]
- Naylor G. J., Dick D. A., Dick E. G. Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium. Psychol Med. 1976 May;6(2):257–263. doi: 10.1017/s0033291700013805. [DOI] [PubMed] [Google Scholar]
- Naylor G. J., Dick D. A., Dick E. G., Le Poidevin D., Whyte S. F. Erythrocyte membrane cation carrier in depressive illness. Psychol Med. 1973 Nov;3(4):502–508. doi: 10.1017/s0033291700054313. [DOI] [PubMed] [Google Scholar]
- Robison G. A., Coppen A. J., Whybrow P. C., Prange A. J. Cyclic A.M.P. in affective disorders. Lancet. 1970 Nov 14;2(7681):1028–1029. doi: 10.1016/s0140-6736(70)92835-7. [DOI] [PubMed] [Google Scholar]
- Smith A. H., Naylor G. S., Moody J. P. Placebo-controlled double-blind trial of mianserin hydrochloride. Br J Clin Pharmacol. 1978;5 (Suppl 1):67S–70S. [PMC free article] [PubMed] [Google Scholar]