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. 1978 Jan;5(1):13–18. doi: 10.1111/j.1365-2125.1978.tb01592.x

Some aspects of the cardiovascular pharmacology of UK 14,275 in patients with coronary artery disease.

K Jennings, P G Jackson, M Monaghan, D E Jewitt
PMCID: PMC1429220  PMID: 619931

Abstract

1. A phosphodiesterase inhibitor, UK 14,275 (Pfizer) was administered intravenously to six patients with suspected coronary artery disease under-going diagnostic cardiac catheterisation to assess its inotropic activity. 2. Intracardiac haemodynamic measurements included pulmonary and systemic arterial pressure. Left ventricular end diastolic pressure and left ventricular dP/dtmax were also measured, in addition to cardiac output using the indocyanine green dye technique. 3. UK 14,275 resulted in a significant increase in LV dP/dtmax and cardiac output. 4. No chronotropic action was observed using this agent. 5. This agent may have potential therapeutic value in the management of cardiovascular failure associated with low cardiac output.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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