Abstract
1 No correlation was found between the rate of gastric emptying and peak plasma propranolol concentrations in six hypertensive patients after single oral doses of 80 mg. 2 In four normal subjects given oral propranolol the peak plasma concentration was highest when a simultaneous injection of metoclopramide and lowest when propantheline was given. The mean time to peak was 1.5 h after metoclopramide, 2.8 h after normal saline and 4.5 h after propantheline. 3 Gastric emptying has some influence on the time of peak plasma propranolol concentrations but individual variation in its bioavailability is determined mainly by first-pass metabolism in the liver.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Evans G. H., Shand D. G. Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man. Clin Pharmacol Ther. 1973 Jul-Aug;14(4):487–493. doi: 10.1002/cpt1973144part1487. [DOI] [PubMed] [Google Scholar]
- George C. F., Orme M. L., Buranapong P., Macerlean D., Breckenridge A. M., Dollery C. T. Contribution of the liver to overall elimination of propranolol. J Pharmacokinet Biopharm. 1976 Feb;4(1):17–27. doi: 10.1007/BF01271441. [DOI] [PubMed] [Google Scholar]
- Jones T., Clark J. C., Kocak N., Cox A. G., Glass H. I. Measurement of gastric emptying using the scintillation camera and 129Cs. Br J Radiol. 1970 Aug;43(512):537–541. doi: 10.1259/0007-1285-43-512-537. [DOI] [PubMed] [Google Scholar]
- McLean C. E., Deane B. C. Propranolol dose determinants including blood level studies. Angiology. 1970 Sep;21(8):536–545. doi: 10.1177/000331977002100806. [DOI] [PubMed] [Google Scholar]
- Shand D. G., Nuckolls E. M., Oates J. A. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112–120. doi: 10.1002/cpt1970111112. [DOI] [PubMed] [Google Scholar]
- Shand D. G., Rangno R. E. The disposition of propranolol. I. Elimination during oral absorption in man. Pharmacology. 1972;7(3):159–168. doi: 10.1159/000136285. [DOI] [PubMed] [Google Scholar]