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. 1978 Feb;5(2):131–134. doi: 10.1111/j.1365-2125.1978.tb01613.x

The effect of tubocurarine and suxamethonium on directly and indirectly elicited contractions of skeletal muscle in unanaesthetized man using single and train of four impulses.

B P Udwadia, S V Gokhale, H C Barbhaiya
PMCID: PMC1429253  PMID: 619946

Abstract

1 Contractions of adductor pollicis in unanaesthetized man were elicited by direct and indirect stimulation. Single twitch responses as well as those by a train of four impulses at 2 Hz for 2 s were elicited for indirect stimulation. 2 After a suitable control period, tubocurarine (0.05 mg/kg) or suxamethonium (0.08 mg/kg) was administered intravenously. 3 A stepwise diminution in the train of four impulses was noticed after tubocurarine. Indirectly elicited contractions due to single stimulus and direct muscle stimulation remained unaltered. 4 Partial blockade of transient duration occured after suxamethonium for single as well as train of four stimuli. Directly elicited contractions remained unchanged. The intensity of blockade depended on the rate of injection of suxamethonium. 5 Indirectly elicited contractions by train of four impulses is a reliable and sensitive method for testing neuromuscular blocking drugs in unanaesthetized man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ali H. H., Savarese J. J. Monitoring of neuromuscular function. Anesthesiology. 1976 Aug;45(2):216–249. doi: 10.1097/00000542-197608000-00009. [DOI] [PubMed] [Google Scholar]
  2. Ali H. H., Utting J. E., Gray C. Stimulus frequency in the detection of neuromuscular block in humans. Br J Anaesth. 1970 Nov;42(11):967–978. doi: 10.1093/bja/42.11.967. [DOI] [PubMed] [Google Scholar]
  3. Ali H. H., Wilson R. S., Savarese J. J., Kitz R. J. The effect of tubocurarine on indirectly elicited train-of-four muscle response and respiratory measurements in humans. Br J Anaesth. 1975 May;47(5):570–574. doi: 10.1093/bja/47.5.570. [DOI] [PubMed] [Google Scholar]
  4. BODMAN R. I. Evaluation of two synthetic curarizing agents in conscious volunteers. Br J Pharmacol Chemother. 1952 Sep;7(3):409–416. doi: 10.1111/j.1476-5381.1952.tb00708.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Berry F. R. Detection of neuromuscular block in man. Preliminary communication. Br J Anaesth. 1966 Dec;38(12):929–935. doi: 10.1093/bja/38.12.929. [DOI] [PubMed] [Google Scholar]
  6. CHURCHILL-DAVIDSON H. C., CHRISTIE T. H. The diagnosis of neuromuscular block in man. Br J Anaesth. 1959 Jul;31:290–301. doi: 10.1093/bja/31.7.290. [DOI] [PubMed] [Google Scholar]
  7. CHURCHILL-DAVIDSON H. C., CHRISTIE T. H., WISE R. P. Dual neuromuscular block in man. Anesthesiology. 1960 Mar-Apr;21:144–149. doi: 10.1097/00000542-196003000-00002. [DOI] [PubMed] [Google Scholar]
  8. Crul J. F., Long G. J., Brunner E. A., Coolen J. M. The changing pattern of neuromuscular blockade caused by succinylcholine in man. Anesthesiology. 1966 Nov-Dec;27(6):729–735. doi: 10.1097/00000542-196611000-00003. [DOI] [PubMed] [Google Scholar]
  9. De Jong R. H., Freund F. G. Characteristics of the neuromuscular block with succinylcholine and decamethonium in man. Anesthesiology. 1967 May-Jun;28(3):583–591. [PubMed] [Google Scholar]
  10. Epstein R. A., Epstein R. M. The electromyogram and the mechanical response of indirectly stimulated muscle in anesthetized man following curarization. Anesthesiology. 1973 Mar;38(3):212–223. doi: 10.1097/00000542-197303000-00003. [DOI] [PubMed] [Google Scholar]
  11. FOLDES F. F. The pharmacology of neuromuscular blocking agents in man. Clin Pharmacol Ther. 1960 May-Jun;1:345–395. doi: 10.1002/cpt196013345. [DOI] [PubMed] [Google Scholar]
  12. KATZ R. L. COMPARISON OF ELECTRICAL AND MECHANICAL RECORDING OF SPONTANEOUS AND EVOKED MUSCLE ACTIVITY. THE CLINICAL VALUE OF CONTINUOUS RECORDING AS AN AID TO THE RATIONAL USE OF MUSCLE RELAXANTS DURING ANESTHESIA. Anesthesiology. 1965 Mar-Apr;26:204–211. doi: 10.1097/00000542-196503000-00012. [DOI] [PubMed] [Google Scholar]
  13. Katz R. L. Electromyographic and mechanical effects of suxamethonium and tubocurarine on twitch, tetanic and post-tetanic responses. Br J Anaesth. 1973 Aug;45(8):849–859. doi: 10.1093/bja/45.8.849. [DOI] [PubMed] [Google Scholar]
  14. Lee-Son S., Pilon R. N., Nahor A., Waud B. E. Use of succinylcholine in the presence of atypical cholinesterase. Anesthesiology. 1975 Oct;43(4):493–496. doi: 10.1097/00000542-197510000-00020. [DOI] [PubMed] [Google Scholar]
  15. Lee C. Dose relationships of phase II, tachyphylaxis and train-of-four fade in suxamethonium-induced dual neuromuscular block in man. Br J Anaesth. 1975 Aug;47(8):841–845. doi: 10.1093/bja/47.8.841. [DOI] [PubMed] [Google Scholar]
  16. MUSHIN W. W., MAPLESON W. W. The assessment of relaxation in man. Br J Anaesth. 1957 Jun;29(6):249–260. doi: 10.1093/bja/29.6.249. [DOI] [PubMed] [Google Scholar]
  17. UNNA K. R., PELIKAN E. W. Evaluation of curarizing drugs in man. VI. Critique of experiments on unanesthetized subjects. Ann N Y Acad Sci. 1951 Oct;54(3):480–492. doi: 10.1111/j.1749-6632.1951.tb39937.x. [DOI] [PubMed] [Google Scholar]
  18. UNNA K. R., PELIKAN E. W., MacFARLANE D. W., CAZORT R. J., SADOVE M. S., NELSON J. T. Evaluation of curarizing agents in man. J Am Med Assoc. 1950 Oct 7;144(6):448–451. doi: 10.1001/jama.1950.02920060010003. [DOI] [PubMed] [Google Scholar]

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