Abstract
1 The effects of selective and non-selective beta-adrenoceptor blockade upon plasma non-esterified fatty acid concentrations in the fasting state and following insulin stress have been studied in normal subjects. 2 Atenolol, propranolol and placebo were compared in a double-blind cross-over trial in eight normal subjects. 3 Atenolol and propranolol significantly lowered plasma non-esterified fatty acid concentrations by a similar degree in the fasting, non-stressed state. This finding suggests that beta1-adrenoceptors are involved in the control of basal lipolysis. 4 Following insulin-induced stress, lower plasma non-esterified fatty acid concentrations were observed with propranolol than with atenolol. This difference may be due to beta2-adrenoceptor involvement in the stress mechanisms controlling lipolysis, or to the differences in the water-lipid solubility properties of these drugs.
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- Ablad B., Börjesson I., Carlsson E., Johnsson G. Effects of metoprolol and propranolol on some metabolic responses to catecholamines in the anaesthetized dog. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):85–95. doi: 10.1111/j.1600-0773.1975.tb03325.x. [DOI] [PubMed] [Google Scholar]
- Arnold A. Differentiation of receptors activated by catecholamines. 3. Farmaco Sci. 1972 Jan;27(1):79–100. [PubMed] [Google Scholar]
- Barrett A. M., Carter J., Fitzgerald J. D., Hull R., Le Count D. A new type of cardioselective adrenoceptive blocking drug. Br J Pharmacol. 1973 Jun;48(2):340P–340P. [PMC free article] [PubMed] [Google Scholar]
- Butcher R. W., Baird C. E., Sutherland E. W. Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells. J Biol Chem. 1968 Apr 25;243(8):1705–1712. [PubMed] [Google Scholar]
- Cardon P. V., Weiss J. L., Mueller P. S. Effects of small intravenous doses of epinephrine on serum insulin, glucose tolerance and serum free fatty acids. Diabetes. 1974 Sep;23(9):743–747. doi: 10.2337/diab.23.9.743. [DOI] [PubMed] [Google Scholar]
- Fain J. N. Biochemical aspects of drug and hormone action on adipose tissue. Pharmacol Rev. 1973 Mar;25(1):67–118. [PubMed] [Google Scholar]
- GOLDFIEN A., MOORE R., ZILELI S., HAVENS L. L., BOLING L., THORN G. W. Plasma epinephrine and norepinephrine levels during insulin-induced hypoglycemia in man. J Clin Endocrinol Metab. 1961 Mar;21:296–304. doi: 10.1210/jcem-21-3-296. [DOI] [PubMed] [Google Scholar]
- Himms-Hagen J. Sympathetic regulation of metabolism. Pharmacol Rev. 1967 Sep;19(3):367–461. [PubMed] [Google Scholar]
- PILKINGTON T. R., LOWE R. D., ROBINSON B. F., TITTERINGTON E. Effect of adrenergic blockade on glucose and fatty-acid mobilisation in man. Lancet. 1962 Aug 18;2(7251):316–317. doi: 10.1016/s0140-6736(62)90105-8. [DOI] [PubMed] [Google Scholar]
- Pilkington T. R., Lowe R. D., Foster R., Robinson B. F., Antonis A. Effect of sympathomimetic compounds with beta-adrenergic effects on plasma free fatty acids in man. J Lipid Res. 1966 Jan;7(1):73–76. [PubMed] [Google Scholar]
- Pinter E. J., Pattee C. J. Effect of beta-adrenergic blockade on resting and stimulated fat mobilization. J Clin Endocrinol Metab. 1967 Oct;27(10):1441–1450. doi: 10.1210/jcem-27-10-1441. [DOI] [PubMed] [Google Scholar]
- TROUT D. L., ESTES E. H., Jr, FRIEDBERG S. J. Titration of free fatty acids of plasma: a study of current methods and a new modification. J Lipid Res. 1960 Apr;1:199–202. [PubMed] [Google Scholar]