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. 1978 Mar;5(3):249–254. doi: 10.1111/j.1365-2125.1978.tb01632.x

Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

M C Bateson, D Maclean, J R Evans, I A Bouchier
PMCID: PMC1429265  PMID: 656270

Abstract

1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and followed monthly for 6 months. Nine of these patients were then followed for a further month on placebo capsules and thereafter monthly for a further 6 months on clofibrate 2 g daily. 2 The mean serum triglyceride level fell by 36% after dietary treatment alone (P less than 0.05) and by 47% from initial values on diet plus chenodeoxycholic acid (P less than 0.01). In the nine patients who proceeded to clofibrate therapy there was a rise in triglyceride levels on placebo capsules to the level achieved by diet alone, and a further fall on diet plus clofibrate of 47% of initial values (P less than 0.05). 3 Chenodeoxycholic acid therapy is effective in the management of hypertriglyceridaemia not completely cured by dietary measures, and may be as efficacious as clofibrate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbara L., Roda E., Roda A., Sama C., Festi D., Mazzella G., Aldini R. The medical treatment of cholesterol gallstones: experience with chenodeoxycholic acid. Digestion. 1976;14(3):209–219. doi: 10.1159/000197933. [DOI] [PubMed] [Google Scholar]
  2. Beaumont J. L., Carlson L. A., Cooper G. R., Fejfar Z., Fredrickson D. S., Strasser T. Classification of hyperlipidaemias and hyperlipoproteinaemias. Bull World Health Organ. 1970;43(6):891–915. [PMC free article] [PubMed] [Google Scholar]
  3. Bell G. D., Lewis B., Petrie A., Dowling R. H. Serum lipids in cholelithiasis: effect of chenodeoxycholic acid therapy. Br Med J. 1973 Sep 8;3(5879):520–523. doi: 10.1136/bmj.3.5879.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bell G. D., Mok H. Y., Thwe M., Murphy G. M., Henry K., Dowling R. H. Liver structure and function in cholelithiasis: effect of chenodeoxycholic acid. Gut. 1974 Mar;15(3):165–172. doi: 10.1136/gut.15.3.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carlson L. A., Böttiger L. E. Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study. Lancet. 1972 Apr 22;1(7756):865–868. doi: 10.1016/s0140-6736(72)90738-6. [DOI] [PubMed] [Google Scholar]
  6. FREDRICKSON D. S., LEES R. S. A SYSTEM FOR PHENOTYPING HYPERLIPOPROTEINEMIA. Circulation. 1965 Mar;31:321–327. doi: 10.1161/01.cir.31.3.321. [DOI] [PubMed] [Google Scholar]
  7. Goldstein J. L., Hazzard W. R., Schrott H. G., Bierman E. L., Motulsky A. G. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest. 1973 Jul;52(7):1533–1543. doi: 10.1172/JCI107331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Grundy S. M., Ahrens E. H., Jr, Salen G., Schreibman P. H., Nestel P. J. Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia. J Lipid Res. 1972 Jul;13(4):531–551. [PubMed] [Google Scholar]
  9. Hartmann G., Forster G. Clinical evaluation of a new hypolipidemic drug, CIBA 13,437-Su. J Atheroscler Res. 1969 Sep-Oct;10(2):235–246. doi: 10.1016/s0368-1319(69)80011-6. [DOI] [PubMed] [Google Scholar]
  10. Hoffman N. E., Hofmann A. F., Thistle J. L. Effect of bile acid feeding on cholesterol metabolism in gallstone patients. Mayo Clin Proc. 1974 Apr;49(4):236–239. [PubMed] [Google Scholar]
  11. Kannel W. B., Castelli W. P., Gordon T., McNamara P. M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med. 1971 Jan;74(1):1–12. doi: 10.7326/0003-4819-74-1-1. [DOI] [PubMed] [Google Scholar]
  12. Levy R. I., Morganroth J., Rifkind B. M. Treatment of hyperlipidemia. N Engl J Med. 1974 Jun 6;290(23):1295–1301. doi: 10.1056/NEJM197406062902306. [DOI] [PubMed] [Google Scholar]
  13. Lorimer A. R., Cox F. C., Greaves D. A., Jubb J. S., Hawthorne V. M., Morgan H. G., Lawrie T. D. Prevalence of hyperlipoproteinaemia in apparently healthy men. Br Heart J. 1974 Feb;36(2):192–196. doi: 10.1136/hrt.36.2.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Miller N. E., Nestel P. J. Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia. Lancet. 1974 Oct 19;2(7886):929–931. doi: 10.1016/s0140-6736(74)91134-9. [DOI] [PubMed] [Google Scholar]
  15. Sturdevant R. A., Pearce M. L., Dayton S. Increased prevalence of cholelithiasis in men ingesting a serum-cholesterol-lowering diet. N Engl J Med. 1973 Jan 4;288(1):24–27. doi: 10.1056/NEJM197301042880106. [DOI] [PubMed] [Google Scholar]
  16. Tabaqchali S., Chait A., Harrison R., Lewis B. Experience with simplified scheme of treatment of hyperlipidaemia. Br Med J. 1974 Aug 10;3(5927):377–380. doi: 10.1136/bmj.3.5927.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Whyte H. M. Potential effect on coronary-heart-disease morbidity of lowering the blood-cholesterol. Lancet. 1975 Apr 19;1(7912):906–910. doi: 10.1016/s0140-6736(75)91698-0. [DOI] [PubMed] [Google Scholar]
  18. Wilson W. S., Hulley S. B., Burrows M. I., Nichaman M. Z. Serial lipid and lipoprotein responses to the American Heart Association fat-controlled diet. Am J Med. 1971 Oct;51(4):491–503. doi: 10.1016/0002-9343(71)90255-5. [DOI] [PubMed] [Google Scholar]
  19. van Waes L., de Weert M., Schurgers M., Beeckman P., Barbier F., Demeulenaere L. Traitement de la lithiase biliaire par l'acide chénique. Etat actuel d'une étude prospective. Acta Gastroenterol Belg. 1975 Jan-Feb;38(1-2):24–33. [PubMed] [Google Scholar]

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