Abstract
1 The kinetics of sodium valproate (di-n-propyl-acetate, Depakine®) have been studied in six healthy volunteers after administration of single oral and intravenous doses (800 mg).
2 Kinetic parameters were similar for both routes of administration. In all subjects absorption was rapid and complete. Half-lives ranged from 11-15 h. Apparent volumes of distribution were relatively low (0.147 ± 0.004 l/kg) and showed little variation amongst individuals.
3 The factors responsible for the poor correlation between dosage and serum levels during chronic treatment and therapeutic implications are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gibaldi M. Effect of mode of administration on drug distribution in a two-compartment open system. J Pharm Sci. 1969 Mar;58(3):327–331. doi: 10.1002/jps.2600580308. [DOI] [PubMed] [Google Scholar]
- Haigh D., Forsythe W. I. The treatment of childhood epilepsy with sodium valproate. Dev Med Child Neurol. 1975 Dec;17(6):743–748. doi: 10.1111/j.1469-8749.1975.tb04698.x. [DOI] [PubMed] [Google Scholar]
- Klotz U., Antonin K. H. Pharmacokinetics and bioavailability of sodium valproate. Clin Pharmacol Ther. 1977 Jun;21(6):736–743. doi: 10.1002/cpt1977216736. [DOI] [PubMed] [Google Scholar]
- Loiseau P., Brachet A., Henry P. Concentration of dipropylacetate in plasma. Epilepsia. 1975 Nov;16(4):609–615. doi: 10.1111/j.1528-1157.1975.tb04743.x. [DOI] [PubMed] [Google Scholar]
- MEUNIER H., CARRAZ G., NEUNIER Y., EYMARD P., AIMARD M. [Pharmacodynamic properties of N-dipropylacetic acid]. Therapie. 1963 Mar-Apr;18:435–438. [PubMed] [Google Scholar]
- Pinder R. M., Brogden R. N., Speight T. M., Avery G. S. Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs. 1977 Feb;13(2):81–123. doi: 10.2165/00003495-197713020-00001. [DOI] [PubMed] [Google Scholar]
- Richens A., Ahmad S. Controlled trial of sodium valproate in severe epilepsy. Br Med J. 1975 Nov 1;4(5991):255–256. doi: 10.1136/bmj.4.5991.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schobben F., van der Kleijn E., Gabreëls F. J. Pharmacokinetics of di-n-propylacetate in epileptic patients. Eur J Clin Pharmacol. 1975 Feb 28;8(2):97–105. doi: 10.1007/BF00561557. [DOI] [PubMed] [Google Scholar]
- Simon D., Penry J. K. Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review. Epilepsia. 1975 Nov;16(4):549–573. doi: 10.1111/j.1528-1157.1975.tb04738.x. [DOI] [PubMed] [Google Scholar]
- Wagner J. G., Northam J. I., Alway C. D., Carpenter O. S. Blood levels of drug at the equilibrium state after multiple dosing. Nature. 1965 Sep 18;207(5003):1301–1302. doi: 10.1038/2071301a0. [DOI] [PubMed] [Google Scholar]