Side-effects of mixed agonist-antagonist analgesics used in sequential anaesthesia

. 1979;7(Suppl 3):323S–326S. doi: 10.1111/j.1365-2125.1979.tb04708.x

PMCID: PMC1429303 PMID: 465294

Abstract

1 Mixed agonist-antagonist analgesics have analgesic action but also possess a range of side-effects.

2 Narcotic antagonists do not reverse the non-specific effects of opiates.

3 Under certain circumstances the effects of agonists and mixed agonist-antagonists can be additive.

4 Chronic dosage of mixed agonist-antagonists leads to a lower level of dependence than that observed with the standard narcotics.

5 Mixed agonist-antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.

These references are in PubMed. This may not be the complete list of references from this article.

Coltart D. J., Malcolm A. D. Pharmacological and clinical importance of narcotic antagonists and mixed antagonists--use in cardiology. Br J Clin Pharmacol. 1979;7 (Suppl 3):309S–311S. doi: 10.1111/j.1365-2125.1979.tb04705.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
Heel R. C., Brogden R. N., Speight T. M., Avery G. S. Butorphanol: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1978 Dec;16(6):473–505. doi: 10.2165/00003495-197816060-00001. [DOI] [PubMed] [Google Scholar]
Nagashima H., Karamanian A., Malovany R., Radnay P., Ang M., Koerner S., Foldes F. F. Respiratory and circulatory effects of intravenous butorphanol and morphine. Clin Pharmacol Ther. 1976 Jun;19(6):738–745. doi: 10.1002/cpt1976196738. [DOI] [PubMed] [Google Scholar]
Orwin J. M., Orwin J., Price M. A double blind comparison of buprenorphine and morphine in conscious subjects following administration by the intramuscular route. Acta Anaesthesiol Belg. 1976;27(3):171–181. [PubMed] [Google Scholar]
Rance M. J. Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs. Br J Clin Pharmacol. 1979;7 (Suppl 3):281S–286S. doi: 10.1111/j.1365-2125.1979.tb04701.x. [DOI] [PMC free article] [PubMed] [Google Scholar]