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. 1979;7(Suppl 3):281S–286S. doi: 10.1111/j.1365-2125.1979.tb04701.x

Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs

Michael J Rance
PMCID: PMC1429313  PMID: 223616

Abstract

1 The pharmacology of analgesic drugs with mixed agonist-antagonist action is reviewed in the light of the theory of drug action at single and multiple receptors.

2 Evidence for a heterogeneous population of opiate receptors in mammalian brain and in isolated tissue preparations is discussed.

3 The unusual pharmacological and pharmacokinetic profiles of the oripavine derivative buprenorphine are discussed in relation to the action of the drug at a molecular level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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