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. 1979;7(Suppl 2):167S–172S. doi: 10.1111/j.1365-2125.1979.tb04687.x

Effect of β-blockers on exercise double product (systolic blood pressure × heart rate)

R A Vukovich, J E Foley, B Brown, D A Willard, M Buckley, D O'Kelly, D Fitzgerald, W Tormey, A Darragh
PMCID: PMC1429319  PMID: 37871

Abstract

1 The effect of single oral doses of six β-receptor antagonists on exercise-induced changes in double product (systolic blood pressure × heart rate) were studied in 25 human volunteers.

2 Three doses of propranolol, nadolol, oxprenolol, pindolol, timolol and atenolol were selected for study on the basis of in vivo β-blocking potency.

3 Although all β-blockers studied reduced the double product response to exercise, the pharmacodynamics of this effect differed markedly.

4 Pharmacodynamic half-lives, estimated for the drugs tested, were 39 h for nadolol, atenolol 21 h, timolol 15 h, oxprenolol 13 h, propranolol 11 and pindolol 8 h.

5 These results suggest that the clinical choice of a β-blocker with the least problems of compliance can be made on the basis of pharmacodynamics as well as pharmacological profile.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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