Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1979;7(Suppl 2):219S–224S. doi: 10.1111/j.1365-2125.1979.tb04693.x

β-Adrenoceptor-blocking agents and the kidney

Effect of nadolol and propranolol on the renal circulation

Norman K Hollenberg, Douglass F Adams, Doris N McKinstry, Gordon H Williams, Louis J Borucki, Jay M Sullivan
PMCID: PMC1429339  PMID: 37877

Abstract

1 Nadolol was administered intravenously to five hypertensive patients and three healthy volunteers in balance on a 10 mEq sodium intake.

2 Nadolol (0.3-10.0 μg/kg) induced a significant, dose-related increase in renal blood flow, measured with radioxenon, with a maximum increase of 72 ± 4 ml/100g/min (26%) at 3.0 μg/kg.

3 Heart rate and plasma renin activity decreased significantly over the same dose range.

4 The renal vascular response to nadolol contrasts sharply with those found with other β-adrenoceptor-blocking agents.

5 The magnitude of the increase in renal blood flow, its time-course and the parallel fall in plasma renin activity raise the possibility that the renal vasodilatation reflects the reversal of angiotensin's influence on the renal arterial bed.

Full text

PDF
219S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdel-Razzak M. Effect of some beta-adrenergic blocking drugs on the renal bloow flow in dogs. Arch Int Pharmacodyn Ther. 1977 Oct;229(2):227–234. [PubMed] [Google Scholar]
  2. Bianchi C., Bonadio M., Donadio C., Tramonti G., Figus S., Papalexiou P. Acute effects of tolamolol on renal function in hypertensive patients. Experientia. 1976 Dec 15;32(12):1565–1566. doi: 10.1007/BF01924456. [DOI] [PubMed] [Google Scholar]
  3. Bufano G., Piacentini L. Studio comparativo dell'influenza esercitata da agonisti e antagonisti beta-adrenergici sulla funzione renale dell'uomo normale. Minerva Med. 1969 Apr 4;60(27):1229–1232. [PubMed] [Google Scholar]
  4. Carrière S. Effect of norepinephrine, isoproterenol, and adrenergic blockers upon the intrarenal distribution of blood flow. Can J Physiol Pharmacol. 1969 Feb;47(2):199–208. doi: 10.1139/y69-034. [DOI] [PubMed] [Google Scholar]
  5. Cooper N., Barry W. F., Jr, Labay P., Boyarsky S. Evidence of renal hemodynamic changes encountered after dichloroisoproterenol. Invest Urol. 1967 Jan;4(4):366–371. [PubMed] [Google Scholar]
  6. Emanuel R. L., Cain J. P., Williams G. H. Double antibody radioimmunoassay of renin activity and angiotensin II in human peripheral plasma. J Lab Clin Med. 1973 Apr;81(4):632–640. [PubMed] [Google Scholar]
  7. Epstein S. E., Braunwald E. The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart disease. Ann Intern Med. 1966 Jul;65(1):20–27. doi: 10.7326/0003-4819-65-1-20. [DOI] [PubMed] [Google Scholar]
  8. Fenyvesi T., Kállay K. The presence of beta-adrenergic receptors in the renal vascular bed. Acta Physiol Acad Sci Hung. 1970;38(2):159–166. [PubMed] [Google Scholar]
  9. Greenblatt D. J., Koch-Weser J. Adverse reactions to propranolol in hospitalized medical patients: a report from the Boston Collaborative Drug Surveillance Program. Am Heart J. 1973 Oct;86(4):478–484. doi: 10.1016/0002-8703(73)90139-7. [DOI] [PubMed] [Google Scholar]
  10. Heierli C., Thoelen H., Radielovic P. Renal function following a single dose of pindolol in hypertensive patients with varying degrees of impairment of renal function. Int J Clin Pharmacol Biopharm. 1977 Feb;15(2):65–71. [PubMed] [Google Scholar]
  11. Hollenberg N. K., Adams D. F., Solomon H., Chenitz W. R., Burger B. M., Abrams H. L., Merrill J. P. Renal vascular tone in essential and secondary hypertension: hemodynamic and angiographic responses to vasodilators. Medicine (Baltimore) 1975 Jan;54(1):29–44. doi: 10.1097/00005792-197501000-00002. [DOI] [PubMed] [Google Scholar]
  12. Hollenberg N. K., Sandor T., Conroy M., Adams D. F., Solomon H. S., Abrams H. L., Merrill J. P. Xenon transit through the oliguric human kidney: analysis by maximum likelihood. Kidney Int. 1973 Mar;3(3):177–185. doi: 10.1038/ki.1973.26. [DOI] [PubMed] [Google Scholar]
  13. Hollenberg N. K., Williams G. H., Taub K. J., Ishikawa I., Brown C., Adams D. F. Renal vascular response to interruption of the renin-angiotensin system in normal man. Kidney Int. 1977 Oct;12(4):285–293. doi: 10.1038/ki.1977.113. [DOI] [PubMed] [Google Scholar]
  14. Ibsen H., Sederberg-Olsen P. Changes in glomerular filtration rate during long-term treatment with propranolol in patients with arterial hypertension. Clin Sci. 1973 Feb;44(2):129–134. doi: 10.1042/cs0440129. [DOI] [PubMed] [Google Scholar]
  15. Krauss X. H., Schalekamp M. A., Kolsters G., Zaal G. A., Birkenhäger W. H. Effects of chronic beta-adrenergic blockade on systemic and renal haemodynamic responses to hyperosmotic saline in hypertensive patients. Clin Sci. 1972 Sep;43(3):385–391. doi: 10.1042/cs0430385. [DOI] [PubMed] [Google Scholar]
  16. Nayler W. G., McInnes I., Swann J. B., Carson V., Lowe T. E. Effect of propranolol, a beta-adrenergic antagonist, on blood flow in the coronary and other vascular fields. Am Heart J. 1967 Feb;73(2):207–216. doi: 10.1016/0002-8703(67)90150-0. [DOI] [PubMed] [Google Scholar]
  17. Nies A. S., McNeil J. S., Schrier R. W. Mechanism of increased sodium reabsorption during propranolol administration. Circulation. 1971 Oct;44(4):596–604. doi: 10.1161/01.cir.44.4.596. [DOI] [PubMed] [Google Scholar]
  18. Pedersen E. B., Mogensen C. E. Effect of antihypertensive treatment on urinary albumin excretion, glomerular filtration rate, and renal plasma flow in patients with essential hypertension. Scand J Clin Lab Invest. 1976 May;36(3):231–237. [PubMed] [Google Scholar]
  19. Sannerstedt R., Conway J. Hemodynamic and vascular responses to antihypertensive treatment with adrenergic blocking agents: a review. Am Heart J. 1970 Jan;79(1):122–127. doi: 10.1016/0002-8703(70)90402-3. [DOI] [PubMed] [Google Scholar]
  20. Schirmeister J., Decot M., Hallauer W., Willmann H. Beta-Receptoren und renale Hämodynamik des Menschen. Arzneimittelforschung. 1966 Jul;16(7):847–850. [PubMed] [Google Scholar]
  21. Stephen S. A. Unwanted effects of propranolol. Am J Cardiol. 1966 Sep;18(3):463–472. doi: 10.1016/0002-9149(66)90071-3. [DOI] [PubMed] [Google Scholar]
  22. Sullivan J. M., Adams D. F., Hollenberg N. K. beta-adrenergic blockade in essential hypertension: reduced renin release despite renal vasoconstriction. Circ Res. 1976 Oct;39(4):532–536. doi: 10.1161/01.res.39.4.532. [DOI] [PubMed] [Google Scholar]
  23. Thompson F. D., Joekes A. M. Letter: Beta-blockade in the presence of renal disease and hypertension. Br Med J. 1974 Jun 8;2(5918):555–556. doi: 10.1136/bmj.2.5918.555-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Warren D. J., Swainson C. P., Wright N. Deterioration in renal function after beta-blockade in patients with chronic renal failure and hypertension. Br Med J. 1974 Apr 27;2(5912):193–194. doi: 10.1136/bmj.2.5912.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wilkinson R., Pickering M., Robson V., Elliott R. W., Kerr D. N. The use of frusemide and propranool in the treatment of the hypertension of chronic renal disease. Scott Med J. 1974;19 (Suppl 1):25–32. doi: 10.1177/00369330740190S106. [DOI] [PubMed] [Google Scholar]
  26. Zech P., Pozet N., Labeeuw M., Sassard J., Bernheim J., Pellet M., Traeger J. Acute renal effects of new beta-adrenergic receptor site blocking agents on renal function. Proc Eur Dial Transplant Assoc. 1976;12:203–209. [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES