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. 1979 Feb;7(2):175–181. doi: 10.1111/j.1365-2125.1979.tb00918.x

The effects of beta-adrenoceptor blockade on renin, angiotensin, aldosterone and catecholamines at rest and during exercise.

P J Lijnen, A K Amery, R H Fagard, T M Reybrouck, E J Moerman, A F De Schaepdryver
PMCID: PMC1429426  PMID: 760750

Abstract

1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of 'active' renin and angiotensin II together with an increase of 'inactive' renin and unchanged 'total' renin. The significant exercise-provoked increases in angiotensin II, plasma renin activity and 'active', 'inactive' and 'total' renin when on placebo, were reduced by metoprolol. 2 No significant change in serum sodium and potassium and in plasma aldosterone was found during beta-adrenoceptor blockade at rest. During exercise plasma aldosterone dropped significantly without any change in serum sodium or potassium. 3 Plasma noradrenaline increased significantly at rest on metoprolol. The increase in plasma noradrenaline and adrenaline during exercise was similar on placebo and on metoprolol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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