Abstract
1. Intravenous heroin was administered to volunteers, in doses of 2.5 and 5 mg to non-dependent subjects and does of 1/6, 1/3 and 1/2 of their prescribed daily does of opiates to dependent subjects, and pupillary responses measured before and three times during the 2 h after injection. 2. Tolerance to the miotic effects of heroin in the dependent subjects was demonstrated--larger doses of heroin were needed to produce the same pupil response in dependent subjects than in non-dependent subjects and the duration of action was shorter in the former group. 3. The effect of concurrent oral methadone medication on pupil response to heroin was demonstrated. Subjects prescribed both methadone and heroin showed smaller control pupil diameters and a reduced dose effect to heroin than did subjects prescribed heroin alone.
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Selected References
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- FRASER H. F., ISBELL H. Comparative effects of 20 mgm. of morphine sulfate on non-addicts and former morphine addicts. J Pharmacol Exp Ther. 1952 Aug;105(4):498–502. [PubMed] [Google Scholar]
- Jasinski D. R., Martin W. R. Evaluation of a new photographic method for assessing pupil diameters. Clin Pharmacol Ther. 1967 Mar-Apr;8(2):271–272. doi: 10.1002/cpt196782271. [DOI] [PubMed] [Google Scholar]
- MARTIN W. R., FRASER H. F. A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts. J Pharmacol Exp Ther. 1961 Sep;133:388–399. [PubMed] [Google Scholar]
- Verebely K., Volavka J., Mulé S., Resnick R. Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment. Clin Pharmacol Ther. 1975 Aug;18(2):180–190. doi: 10.1002/cpt1975182180. [DOI] [PubMed] [Google Scholar]