Abstract
1. The antihypertensive effect of a new beta-adrenoceptor blocking agent, trimepranol (10--14 mg/twice daily), chlorthalidone (50 mg every second day) and their combination was studied in eighteen patients with mild to moderate essential hypertension. In a controlled randomized cross-over study the drugs were given for 6 week periods. 2. A significant and equal decrease in blood pressure was achieved both with trimepranol and chlorthalidone, whereas their combination was significantly more effective. 3. Trimepranol significantly antagonized the chlorthalidone-induced hypokalemia. 4. The results favor the use of diuretic or diuretic-beta-adrenoceptor blocker combination over beta-adrenoceptor blocker monotherapy in the treatment of mild to moderate hypertension.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bengtsson C., Johnsson G., Sannerstedt R., Werkö L. Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate. Br Med J. 1975 Jan 25;1(5951):197–199. doi: 10.1136/bmj.1.5951.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bühler F. R., Laragh J. H., Baer L., Vaughan E. D., Jr, Brunner H. R. Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med. 1972 Dec 14;287(24):1209–1214. doi: 10.1056/NEJM197212142872401. [DOI] [PubMed] [Google Scholar]
- Drayer J. I., Kloppenborg P. W., Festen J., van't Laar A., Benraad T. J. Intrapatient comparison of treatment with chlorthalidone, spironolactone and propranolol in normoreninemic essential hypertension. Am J Cardiol. 1975 Oct 31;36(5):716–721. doi: 10.1016/0002-9149(75)90174-5. [DOI] [PubMed] [Google Scholar]
- Jounela A. J., Pentikäinen P. J., Neuvonen P. J. Antihypertensive effect of trimepranol, a new beta-blocking agent. Int J Clin Pharmacol Biopharm. 1978 Apr;16(4):183–188. [PubMed] [Google Scholar]
- Pentikäinen P. J., Neuvonen P. J., Penttilä A. Assessment of beta-blocking activity of trimepranol in man. Int J Clin Pharmacol Biopharm. 1978 Jun;16(6):279–284. [PubMed] [Google Scholar]
- Sweet C. S., Gaul S. L. Attenuation of hydrochlorothiazide-induced hypokalemia in dogs by a beta-adrenergic blocking drug, timolol. Eur J Pharmacol. 1975 Jun-Jul;32(02):370–374. doi: 10.1016/0014-2999(75)90307-6. [DOI] [PubMed] [Google Scholar]