Abstract
1 Two studies have been carried out to investigate the effect of H1- and H2-receptor blocking agents on histamine-induced bronchoconstriction in non-asthmatic subjects. 2 The H2-receptor blocker cimetidine administered orally had no effect on histamine-induced bronchoconstriction on any of the subjects tested. In three of four subjects, the H1-receptor blocker, chlorpheniramine given orally, inhibited the effect of the histamine in the lung. 3 The effects of intravenous chlorpheniramine and cimetidine, both alone and in combination, upon histamine-induced bronchoconstriction, were also studied. Chlorpheniramine inhibited the effect of the histamine and this was significantly dose related. This was not so with cimetidine and there was no evidence that the dose response curve to chlorpheniramine was affected by the additional administration of cimetidine. 4 The results show that histamine-induced bronchoconstriction in non-asthmatic subjects is not mediated by H2-receptors, but it is likely that H1-receptors are involved.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Black J. W., Owen D. A., Parsons M. E. An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors. Br J Pharmacol. 1975 Jul;54(3):319–324. doi: 10.1111/j.1476-5381.1975.tb07571.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Casterline C. L., Evans R. Further studies on the mechanism of human histamine-induced asthma: the effect of an aerosolized H1 receptor antagonist (diphenhydramine). J Allergy Clin Immunol. 1977 Jun;59(6):420–424. doi: 10.1016/0091-6749(77)90004-5. [DOI] [PubMed] [Google Scholar]
- Dunlop L. S., Smith A. P., Piper P. J. The effect of histamine antagonists on antigen-induced contractions of sensitized human bronchus in vitro [proceedings]. Br J Pharmacol. 1977 Mar;59(3):475P–475P. [PMC free article] [PubMed] [Google Scholar]
- Eyre P. Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide. Br J Pharmacol. 1973 Jun;48(2):321–323. doi: 10.1111/j.1476-5381.1973.tb06920.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Itkin I. H., Anand S. C. The role of atropine as a mediator blocker of induced bronchial obstruction. J Allergy. 1970 Mar;45(3):178–186. doi: 10.1016/0021-8707(70)90126-7. [DOI] [PubMed] [Google Scholar]
- Levi R., Allan G., Zavecz J. H. Cardiac histamine receptors. Fed Proc. 1976 Jun;35(8):1942–1947. [PubMed] [Google Scholar]
- Lichtenstein L. M., Gillespie E. Inhibition of histamine release by histamine controlled by H2 receptor. Nature. 1973 Aug 3;244(5414):287–288. doi: 10.1038/244287a0. [DOI] [PubMed] [Google Scholar]
- Maconochie J. G., Woodings E. P., Richards D. A. Effects of labetalol and propranolol on histamine-induced bronchoconstriction in normal subjects. Br J Clin Pharmacol. 1977 Apr;4(2):157–162. doi: 10.1111/j.1365-2125.1977.tb00688.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marks R., Greaves M. W. Vascular reactions to histamine and compound 48/80 in human skin: suppression by a histamine H2-receptor blocking agent. Br J Clin Pharmacol. 1977 Jun;4(3):367–369. doi: 10.1111/j.1365-2125.1977.tb00725.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Okpako D. T. A vasodepressor action of histamine mediated by H2-receptor activation. Eur J Pharmacol. 1974 Nov;29(1):10–14. doi: 10.1016/0014-2999(74)90163-0. [DOI] [PubMed] [Google Scholar]
- Tozzi S., Roth F. E., Tabachnick I. I. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4(4):264–270. doi: 10.1007/BF01965229. [DOI] [PubMed] [Google Scholar]