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. 1979 Mar;7(3):293–297. doi: 10.1111/j.1365-2125.1979.tb00935.x

Quinidine dosage, with special reference to an oral loading dose schedule.

P Collste, R Nordlander
PMCID: PMC1429490  PMID: 427006

Abstract

1 Plasma concentrations of quinidine were analyzed in 52 cardiac patients after different oral loading doses and during different maintenance dosage intervals using both conventional and sustained release preparations of quinidine. 2 The majority of patients reached therapeutic plasma concentrations in the order of 2--4 microgram/ml within 3 h after the loading dose of 600--800 mg of rapidly absorbed ordinary quinidine sulphate tablets and institution of maintenance therapy with sustained release tablets 1 h after the loading dose. 3 The dosage interval of 12 h during maintenance therapy with sustained release tablets gave as acceptable plasma drug fluctuations as an 8 h interval. 4 A large individual variation in plasma concentrations was noticed. Thus monitoring of therapy by plasma concentration analyses is desirable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALL R. E., SOKOLOW M. Factors influencing conversion of chronic atrial fibrillation with special reference to serum quinidine concentration. Circulation. 1956 Oct;14(4 Pt 1):568–583. doi: 10.1161/01.cir.14.4.568. [DOI] [PubMed] [Google Scholar]
  2. BROWN M. G., HOLZMAN D., CREELMAN E. W. Serum quinidine concentration in congestive heart failure. Am J Med Sci. 1953 Feb;225(2):129–131. doi: 10.1097/00000441-195302000-00003. [DOI] [PubMed] [Google Scholar]
  3. Bellet S., Roman L. R., Boza A. Relation between serum quinidine levels and renal function. Studies in normal subjects and patients with congestive failure and renal insufficiency. Am J Cardiol. 1971 Apr;27(4):368–371. doi: 10.1016/0002-9149(71)90432-2. [DOI] [PubMed] [Google Scholar]
  4. Byrne-Quinn E., Wing A. J. Maintenance of sinus rhythm after DC reversion of atrial fibrilllation. A double-blind controlled trial of long-acting quinidine bisulphate. Br Heart J. 1970 May;32(3):370–376. doi: 10.1136/hrt.32.3.370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CONN H. L., Jr, LUCHI R. J. SOME CELLULAR AND METABOLIC CONSIDERATIONS RELATING TO THE ACTION OF QUINIDINE AS A PROTOTYPE ANTIARRHYTHMIC AGENT. Am J Med. 1964 Nov;37:685–699. doi: 10.1016/0002-9343(64)90018-x. [DOI] [PubMed] [Google Scholar]
  6. CRAMER G., ISAKSSON B. QUANTITATIVE DETERMINATION OF QUINIDINE IN PLASMA. Scand J Clin Lab Invest. 1963;15:553–556. doi: 10.1080/00365516309079786. [DOI] [PubMed] [Google Scholar]
  7. CRAMER G., VARNAUSKAS E., WERKO L. A new quinidine preparation with sustained release. Acta Med Scand. 1963 Apr;173:511–519. doi: 10.1111/j.0954-6820.1963.tb17435.x. [DOI] [PubMed] [Google Scholar]
  8. Conrad K. A., Molk B. L., Chidsey C. A. Pharmacokinetic studies of quinidine in patients with arrhythmias. Circulation. 1977 Jan;55(1):1–7. [PubMed] [Google Scholar]
  9. Crouthamel W. G. The effect of congestive heart failure on quinidine pharmacokinetics. Am Heart J. 1975 Sep;90(3):335–339. doi: 10.1016/0002-8703(75)90322-1. [DOI] [PubMed] [Google Scholar]
  10. Data J. L., Wilkinson G. R., Nies A. S. Interaction of quinidine with anticonvulsant drugs. N Engl J Med. 1976 Mar 25;294(13):699–702. doi: 10.1056/NEJM197603252941305. [DOI] [PubMed] [Google Scholar]
  11. Ditlefsen E. M., Bjerkelund C. Quinidine concentration in serum. The stability during maintained treatment with two different types of delayed absorption tablets. Acta Med Scand. 1966 Nov;180(5):537–542. [PubMed] [Google Scholar]
  12. Fremstad D., Bergerud K. Letter: Reduced binding of quinidine in plasma from Vacutainers. Clin Pharmacol Ther. 1976 Jul;20(1):120–120. doi: 10.1002/cpt1976201120. [DOI] [PubMed] [Google Scholar]
  13. Frigo G. M., Perucca E., Teggia-Droghi M., Gatti G., Mussini A., Salerno J. Comparison of quinidine plasma concentration curves following oral administration of some short- and long-acting formulations. Br J Clin Pharmacol. 1977 Aug;4(4):449–454. doi: 10.1111/j.1365-2125.1977.tb00760.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. GOLDBERG W. M., CHAKRABARTI S. G. THE RELATIONSHIP OF DOSAGE SCHEDULE TO THE BLOOD LEVEL OF QUINIDINE, USING ALL AVAILABLE QUINIDINE PREPARATIONS. Can Med Assoc J. 1964 Nov 7;91:991–996. [PMC free article] [PubMed] [Google Scholar]
  15. Henning R., Nyberg G. Serum quinidine levels after administration of three different quinidine preparations. Eur J Clin Pharmacol. 1973 Dec;6(4):239–244. doi: 10.1007/BF00644739. [DOI] [PubMed] [Google Scholar]
  16. Huffman D. H., Hignite C. E. Serum quinidine concentrations: comparison of fluorescence, gas-chromatographic, and gas-chromatographic/mass-spectrometric methods. Clin Chem. 1976 Jun;22(6):810–812. [PubMed] [Google Scholar]
  17. Kessler K. M., Lowenthal D. T., Warner H., Gibson T., Briggs W., Reidenberg M. M. Quinidine elimination in patients with congestive heart failure or poor renal function. N Engl J Med. 1974 Mar 28;290(13):706–709. doi: 10.1056/NEJM197403282901303. [DOI] [PubMed] [Google Scholar]
  18. Mahon W. A., Mayersohn M., Inaba T. Disposition kinetics of two oral forms of quinidine. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):566–575. doi: 10.1002/cpt1976195part1566. [DOI] [PubMed] [Google Scholar]
  19. Midha K. K., Charette C. GLC determination of quinidine from plasma and whole blood. J Pharm Sci. 1974 Aug;63(8):1244–1247. doi: 10.1002/jps.2600630816. [DOI] [PubMed] [Google Scholar]
  20. Ueda C. T., Hirschfeld D. S., Scheinman M. M., Rowland M., Williamson B. J., Dzindzio B. S. Disposition kinetics of quinidine. Clin Pharmacol Ther. 1976 Jan;19(1):30–36. doi: 10.1002/cpt197619130. [DOI] [PubMed] [Google Scholar]
  21. Ueda C. T., Williamson B. J., Dzindzio B. S. Absolute quinidine bioavailability. Clin Pharmacol Ther. 1976 Sep;20(3):260–265. doi: 10.1002/cpt1976203260. [DOI] [PubMed] [Google Scholar]

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