Abstract
1 The absorption of a single oral dose of cimetidine taken on a fasting stomach or together with a meal was studied in 28 patients before and during 12 weeks treatment with cimetidine. 2 No significant changes in bioavailability were seen during treatment measured as the area under the blood concentration curve (AUC). 3 AUC after a single dose of 400 mg cimetidine was 2.05 times the area after a 200 mg dose. 4 There was a good correlation between AUC and the dose of cimetidine given corrected for body weight (r=0.89). 5 There was no difference in bioavailability if 200 mg cimetidine was taken on a fasting stomach or together with a beef steak meal. 6. During fasting conditions there was a peak in blood concentration at about one hour followed by a second unexplained peak during the third to fifth hour after dose administration. 7 With food the initial rise in blood concentrations was slower and there was only one peak occurring about 2 h after dose administration.
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Selected References
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- Burland W. L., Duncan W. A., Hesselbo T., Mills J. G., Sharpe P. C., Haggie S. J., Wyllie J. H. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Br J Clin Pharmacol. 1975 Dec;2(6):481–486. doi: 10.1111/j.1365-2125.1975.tb00564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henn R. M., Isenberg J. I., Maxwell V., Sturdevant R. A. Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer. N Engl J Med. 1975 Aug 21;293(8):371–375. doi: 10.1056/NEJM197508212930802. [DOI] [PubMed] [Google Scholar]
- Pounder R. E., Williams J. G., Russell R. C., Milton-Thompson G. J., Misiewicz J. J. Inhibition of food-stimulated gastric acid secretion by cimetidine. Gut. 1976 Mar;17(3):161–168. doi: 10.1136/gut.17.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Randolph W. C., Osborne V. L., Walkenstein S. S., Intoccia A. P. High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine. J Pharm Sci. 1977 Aug;66(8):1148–1150. doi: 10.1002/jps.2600660825. [DOI] [PubMed] [Google Scholar]
- Spence R. W., Creak D. R., Celestin L. R. Influence of a meal on the absorption of cimetidine. A new histamine H2-receptor antagonist. Digestion. 1976;14(2):127–132. doi: 10.1159/000197917. [DOI] [PubMed] [Google Scholar]