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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1979;8(Suppl 1):43S–46S. doi: 10.1111/j.1365-2125.1979.tb00455.x

Effects of hypnotic and sleep-inducing drugs on objective assessments of human psychomotor performance and subjective appraisals of sleep and early morning behaviour

I Hindmarch
PMCID: PMC1429635  PMID: 508503

Abstract

1 An acute dose comparison against placebo of the effects of nitrazepam 5 mg and temazepam 15 and 30 mg on measures of arousal and performance and on subjective assessment of sleep was carried out in 20 subjects with a history of using night-time medication for insomnia.

2 Amylobarbitone (100 mg) was included as an active control and each drug was given in hard gelatin capsules. Subjects reported improved sleep with nitrazepam 5 mg and temazepam 30 mg, but there was evidence of impaired performance the next day with temazepam 30 mg.

3 The effect of temazepam 20 mg prepared in the Scherer formulation was compared against placebo in a further ten subjects. The subjects reported improved sleep without evidence of impaired performance the next day.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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