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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1979;8(Suppl 1):63S–68S. doi: 10.1111/j.1365-2125.1979.tb00459.x

Hypnotic efficacy of temazepam

A long-term sleep laboratory evaluation

M M Mitler, Mary A Carskadon, R L Phillips, W R Sterling, V P Zarcone, R Spiegel Jr, C Guilleminault, W C Dement
PMCID: PMC1429637  PMID: 41543

Abstract

1 Temazepam was evaluated in a strictly defined insomniac patient population under sleep laboratory conditions. Two protocols were used: a short-term (26-night) and a long-term (54-night) protocol evaluated the efficacy of the drug administered at night at 15 mg (short-term study) and 30 mg (long-term study), respectively.

2 Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion.

3 Suppression of slow wave sleep was observed at the high dose, but no suppression of REM sleep, found in studies with other benzodiazepines, was noted.

4 No evidence was found for development of tolerance or rebound effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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