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. 1979 Apr;7(4):343–348. doi: 10.1111/j.1365-2125.1979.tb00943.x

Specific radioimmunoassay of amitriptyline and nortriptyline.

D J Brunswick, B Needelman, J Mendels
PMCID: PMC1429641  PMID: 444353

Abstract

1 Antisera to nortriptyline were prepared by immunizing rabbits with N-succinylnortriptyline--bovine serum albumin conjugate. 2 A sensitive radioimmunoassay has been developed for the tricyclic antidepressants amitriptyline and nortriptyline. 3 amitriptyline and nortriptyline are separated from each other and from interfering metabolites before assay. 4 Using [3H]-imipramine and [3H]-succinylnortriptyline as tracers the radioimmunoassay can measure amitriptyline and nortriptyline levels down to 2--3 ng/ml using 0.05 ml plasma sample. 5 Agreement between the radioimmunoassay and a gas-chromatographic assay was excellent for both amitriptyline and nortriptyline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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