Abstract
1 The hypotensive effect of single daily dosing with atenolol 100 mg and chlorthalidone 25 mg given alone or in combination has been assessed in a double-blind, crossover, placebo controlled trial in fifteen hypertensive patients. 2 Average lying blood pressures were: Placebo 155.4/103.9 mm Hg, atenolol 134.6/85.8 mm Hg, chlorthalidone 139.5/90.1 mm Hg, combination 127.7/82.5 mm Hg. 3 The effect of the combination therapy in reducing lying diastolic pressure compared with placebo (a fall of 21.4 mm Hg) was significantly less than the 31.9 mm Hg fall predicted from the sum of the individual effects (P = 0.01). 4 Observations on blood pressure at rest and under mental, isometric and bicycle ergometer stress were made pre-dose and post-dose for a 12 h period at the end of the last treatment period. 5 Lying blood pressure declined from the zero hour (pre-dose) reading on all treatments to a low at 15.00--18.00 h and then rose again. 6 The rise in systolic blood pressure after isometric exercise and mental stress was of a similar magnitude with all four treatment regimes. 7 Atenolol, alone and in combination with chlorthalidone, reduced the blood pressure and the pulse rate increase on exercise 2 h post-dose when compared with readings 24 h post-dose. 8 Once daily dosing with a combination of atenolol and chlorthalidone produced a fall in supine blood pressure over a 24 h period but the effect on exercise induced changes was not uniform over this period.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bulpitt C. J., Dollery C. T., Carne S. A symptom questionnaire for hypertensive patients. J Chronic Dis. 1974 Aug;27(6):309–323. doi: 10.1016/0021-9681(74)90094-0. [DOI] [PubMed] [Google Scholar]
- CRANSTON W. I., JUEL-JENSEN B. E., SEMMENCE A. M., JONES R. P., FORBES J. A., MUTCH L. M. EFFECTS OF ORAL DIURETICS ON RAISED ARTERIAL PRESSURE. Lancet. 1963 Nov 9;2(7315):966–970. doi: 10.1016/s0140-6736(63)90671-8. [DOI] [PubMed] [Google Scholar]
- Chalmers J., Tiller D., Horvath J., Bune A. Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial. Lancet. 1976 Aug 14;2(7981):328–331. doi: 10.1016/s0140-6736(76)92589-7. [DOI] [PubMed] [Google Scholar]
- Douglas-Jones A. P., Cruickshank J. M. Once-daily dosing with Atenolol in patients with mild or moderate hypertension. Br Med J. 1976 Apr 24;1(6016):990–991. doi: 10.1136/bmj.1.6016.990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gatley M. S. To be taken as directed. J R Coll Gen Pract. 1968 Jul;16(1):39–44. [PMC free article] [PubMed] [Google Scholar]
- Haynes R. B., Sackett D. L., Gibson E. S., Taylor D. W., Hackett B. C., Roberts R. S., Johnson A. L. Improvement of medication compliance in uncontrolled hypertension. Lancet. 1976 Jun 12;1(7972):1265–1268. doi: 10.1016/s0140-6736(76)91737-2. [DOI] [PubMed] [Google Scholar]
- Hettiarachchi J., Ramsay L. E., Davies D. L., Fraser R., Watson W. S. Amelioration of bendrofluazide-induced hypokalemia by timolol. Clin Pharmacol Ther. 1977 Jul;22(1):58–62. doi: 10.1002/cpt197722158. [DOI] [PubMed] [Google Scholar]
- Jeffers T. A., Webster J., Petrie J. C., Barker N. P. Atenolol once-daily in hypertension. Br J Clin Pharmacol. 1977 Oct;4(5):523–527. doi: 10.1111/j.1365-2125.1977.tb00780.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martin C. E., Shaver J. A., Leon D. F., Thompson M. E., Reddy P. S., Leonard J. J. Autonomic mechanisms in hemodynamic responses to isometric exercise. J Clin Invest. 1974 Jul;54(1):104–115. doi: 10.1172/JCI107731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Myers M. G., Lewis G. R., Steiner J., Dollery C. T. Atenolol in essential hypertension. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):502–507. doi: 10.1002/cpt1976195part1502. [DOI] [PubMed] [Google Scholar]
- Nyberg G., Graham R. M., Stokes G. S. The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade. Br J Clin Pharmacol. 1977 Aug;4(4):469–474. doi: 10.1111/j.1365-2125.1977.tb00764.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearson R. M., Bending M. R., Bulpitt C. J., George C. F., Hole D. R., Williams F. M., Breckenridge A. M. Trial of combination of guanethidine and oxprenolol in hypertension. Br Med J. 1976 Apr 17;1(6015):933–936. doi: 10.1136/bmj.1.6015.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tweeddale M. G., Ogilvie R. I., Ruedy J. Antihypertensive and biochemical effects of chlorthalidone. Clin Pharmacol Ther. 1977 Nov;22(5 Pt 1):519–527. doi: 10.1002/cpt1977225part1519. [DOI] [PubMed] [Google Scholar]