Abstract
1 Forty-one patients with mild to moderate hypertension have been treated with labetalol for up to 5 years. 2 Mean BP before treatment was 180/107 mm Hg, after 2--3 yr treatment was 136/81 mmHg and after 5 yr was 136/74 mmHg. 3 One patient developed a licheniform rash and two patients have died of myocardial infarction. No other side-effects, not already observed in a previously reported double-blind trial, have emerged.
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- BOSHELL B. R., WILENSKY A. S., BARRETT J. C., ALMON J. V. Acetohexamide: comparison with other sulfonylurea compounds in the treatment of diabetes mellitus. Clin Pharmacol Ther. 1962 Nov-Dec;3:750–757. doi: 10.1002/cpt196236750. [DOI] [PubMed] [Google Scholar]
- Gange R. W., Jones E. W. Bullous lichen planus caused by labetalol. Br Med J. 1978 Apr 1;1(6116):816–817. doi: 10.1136/bmj.1.6116.816-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hamilton C. A., Jones D. H., Dargie H. J., Reid J. L. Does labetalol increase excretion of urinary catecholamines? Br Med J. 1978 Sep 16;2(6140):800–800. doi: 10.1136/bmj.2.6140.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kane J., Gregg I., Richards D. A. Double-blind trial of labetalol. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):737–741. [PubMed] [Google Scholar]
- Mackie I. A., Seal D. V., Pescod J. M. Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction. Br J Ophthalmol. 1977 May;61(5):354–359. doi: 10.1136/bjo.61.5.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poynter D., Martin L. E., Harrison C., Cook J. Affinity of labetalol for ocular melanin. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):711–720. [PubMed] [Google Scholar]
- Prichard B. N., Boakes A. J. Labetalol in long-term treatment of hypertension. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):743–750. [PubMed] [Google Scholar]
- Pugsley D. J., Armstrong B. K., Nassim M. A., Beilin L. J. Controlled comparison of labetalol and propranolol in the management of severe hypertension. Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):777–782. [PubMed] [Google Scholar]
- Wilson J. D., Bullock J. Y., Sutherland D. C., Main C., O'Brien K. P. Antinuclear antibodies in patients receiving non-practolol beta-blockers. Br Med J. 1978 Jan 7;1(6104):14–16. doi: 10.1136/bmj.1.6104.14. [DOI] [PMC free article] [PubMed] [Google Scholar]