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. 1979 Sep;8(3):237–242. doi: 10.1111/j.1365-2125.1979.tb01008.x

A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.

H Hey, P Matzen, J T Andersen, E Didriksen, B Nielsen
PMCID: PMC1429802  PMID: 497090

Abstract

1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but compared with non-gastroscoped volunteers, there was delay of 0.5--1.5 h in the appearance of peak serum ampicillin concentrations after gastroscopy. 3 Half of the volunteers receiving pivampicillin capsules developed hyperaemia, interstitial bleeding or erosions of the gastric mucous membrane. No such reactions were seen after pivampicillin tablets. 4 In one volunteer, a pivampicillin capsule was trapped in a not previously noticed hiatus hernia and local changes and pain occurred.

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239Figure 2
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240Figure 3
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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