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. 1979 Dec;8(6):581–587. doi: 10.1111/j.1365-2125.1979.tb01048.x

Comparison of propranolol and metoprolol in the management of hyperthyroidism.

L E Murchison, J How, P D Bewsher
PMCID: PMC1429912  PMID: 391258

Abstract

1 Propranolol and metoprolol were both effective in controlling the symptoms and signs of hyperthyroidism. 2 Propranolol caused a highly significant increase in serum reverse T3 concentrations with lesser changes in other serum thyroid hormone levels, whereas metoprolol did not have this effect. 3 Steady-state plasma propranolol and metoprolol levels showed marked inter-individual variation. Metoprolol concentrations showed relatively little intra-individual variability, and could be related to the clinical efficacy of the drug, whereas no such relationship was demonstrated for propranolol.

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Selected References

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  1. Ablad B., Borg K. O., Carlsson E., EK L., Johnson G., Malmfors T., Regårdh C. G. A survey of the pharmacological properties of metoprolol in animals and man. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):7–23. doi: 10.1111/j.1600-0773.1975.tb03318.x. [DOI] [PubMed] [Google Scholar]
  2. Abreau C., Vagenakis A., Azizi F., Portnay G., Braverman L. A single method for measuring total thyroxine and free thyroxine index in serum. J Nucl Med. 1973 Oct;14(10):740–746. [PubMed] [Google Scholar]
  3. Bell J. M., Russell C. J., Nelson J. K., Kelly J. G., McDevitt D. G. Studies of the effect of thyroid dysfunction on the elimination of beta-adrenoreceptor blocking drugs. Br J Clin Pharmacol. 1977 Feb;4(1):79–82. doi: 10.1111/j.1365-2125.1977.tb00672.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CROOKS J., MURRAY I. P., WAYNE E. J. Statistical methods applied to the clinical diagnosis of thyrotoxicosis. Q J Med. 1959 Apr;28(110):211–234. [PubMed] [Google Scholar]
  5. Degen P. H., Riess W. Simplified method for the determination of oxprenolol and other beta-receptor-blocking agents in biological fluids by gas-liquid chromatography. J Chromatogr. 1976 Jun 9;121(1):72–75. doi: 10.1016/s0021-9673(00)82299-2. [DOI] [PubMed] [Google Scholar]
  6. GILSON W. E. Achilles-reflex recording with a simple photomotograph. N Engl J Med. 1959 May 14;260(20):1027–1028. doi: 10.1056/NEJM195905142602008. [DOI] [PubMed] [Google Scholar]
  7. Georges L. P., Santangelo R. P., Mackin J. F., Canary J. J. Metabolic effects of propranolol in thyrotoxicosis. I. Nitrogen, calcium, and hydroxyproline. Metabolism. 1975 Jan;24(1):11–21. doi: 10.1016/0026-0495(75)90003-7. [DOI] [PubMed] [Google Scholar]
  8. Harrower A. D., Fyffe J. A., Horn D. B., Strong J. A. Thyroxine and triiodothyronine levels in hyperthyroid patients during treatment with propranolol. Clin Endocrinol (Oxf) 1977 Jul;7(1):41–44. doi: 10.1111/j.1365-2265.1977.tb02938.x. [DOI] [PubMed] [Google Scholar]
  9. Kallner G., Ljunggren J. G., Tryselius M. The effect of propranolol on serum levels of T4, T3 and reverse-T3 in hyperthyroidism. Acta Med Scand. 1978;204(1-2):35–37. doi: 10.1111/j.0954-6820.1978.tb08394.x. [DOI] [PubMed] [Google Scholar]
  10. Kristensen B. O., Weeke J. Propranolol-induced increments in total and free serum thyroxine in patients with essential hypertension. Clin Pharmacol Ther. 1977 Dec;22(6):864–867. doi: 10.1002/cpt1977226864. [DOI] [PubMed] [Google Scholar]
  11. Larsson S., Svedmyr N. Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors. Scand J Respir Dis. 1977;58(1):5–10. [PubMed] [Google Scholar]
  12. Lindsay R., Ramsay L. E., Hettiarrachchi J., Davies D. L., Beastall G. H. Serum and urine phosphate during short-term beta-adrenergic blockade in healthy men. Clin Pharmacol Ther. 1978 Dec;24(6):650–653. doi: 10.1002/cpt1978246650. [DOI] [PubMed] [Google Scholar]
  13. Ljunggren J. G., Persson B. Preoperative treatment of thyrotoxicosis with a beta-adrenergic blocking agent. Acta Chir Scand. 1975;141(8):715–718. [PubMed] [Google Scholar]
  14. Lotti G., Delitala G., Devilla L., Alagna S., Masala A. Reduction of plasma triiodothyronine (T3) induced by propranolol. Clin Endocrinol (Oxf) 1977 Jun;6(6):405–410. doi: 10.1111/j.1365-2265.1977.tb03322.x. [DOI] [PubMed] [Google Scholar]
  15. Marsden C. D., Gimlette T. M., McAllister R. G., Owen D. A., Miller T. N. Effect of beta-adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients. Acta Endocrinol (Copenh) 1968 Mar;57(3):353–362. doi: 10.1530/acta.0.0570353. [DOI] [PubMed] [Google Scholar]
  16. McDevitt D. G., Nelson J. K. Comparative trial of atenolol and propranolol in hyperthyroidism. Br J Clin Pharmacol. 1978 Sep;6(3):233–237. doi: 10.1111/j.1365-2125.1978.tb04590.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mincey E. K., Thorson S. C., Brown J. L., Morrison R. T., McIntosh H. W. A new parameter of thyroid function--the effective thyroxine ratio. J Nucl Med. 1972 Feb;13(2):165–168. [PubMed] [Google Scholar]
  18. Murchison L. E., Bewsher P. D., Chesters M. I., Ferrier W. R. Comparison of propranolol and practolol in the management of hyperthyroidism. Br J Clin Pharmacol. 1976 Apr;3(2):273–277. doi: 10.1111/j.1365-2125.1976.tb00603.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pimstone N., Marine N., Pimstone B. Beta-adrenergic blockade in thyrotoxic myopathy. Lancet. 1968 Dec 7;2(7580):1219–1220. doi: 10.1016/s0140-6736(68)91697-8. [DOI] [PubMed] [Google Scholar]
  20. Saunders J., Hall S. E., Crowther A., Sönksen P. H. The effect of propranolol on thyroid hormones and oxygen consumption in thyrotoxicosis. Clin Endocrinol (Oxf) 1978 Jul;9(1):67–72. doi: 10.1111/j.1365-2265.1978.tb03573.x. [DOI] [PubMed] [Google Scholar]
  21. Seth J., Rutherford F. J., McKenzie I. Solid-phase radioimmunoassay of thyroxine in untreated serum. Clin Chem. 1975 Sep;21(10):1406–1413. [PubMed] [Google Scholar]
  22. Shand D. G. Individualization of propranolol therapy. Med Clin North Am. 1974 Sep;58(5):1063–1069. doi: 10.1016/s0025-7125(16)32102-2. [DOI] [PubMed] [Google Scholar]
  23. Shand D. G., Nuckolls E. M., Oates J. A. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112–120. doi: 10.1002/cpt1970111112. [DOI] [PubMed] [Google Scholar]
  24. Skinner C., Gaddie J., Palmer K. N. Comparison of effects of metoprolol and propranolol on asthmatic airway obstruction. Br Med J. 1976 Feb 28;1(6008):504–504. doi: 10.1136/bmj.1.6008.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. TAYLOR J. A. A personality scale of manifest anxiety. J Abnorm Psychol. 1953 Apr;48(2):285–290. doi: 10.1037/h0056264. [DOI] [PubMed] [Google Scholar]
  26. Tevaarwerk G. J., Malik M. H., Boyd D. Preliminary report on the use of propranolol in thyrotoxicosis: I. Effect on serum thyroxine, triiodothyronine and reverse triiodothyronine concentrations. Can Med Assoc J. 1978 Aug 26;119(4):350-1, 360. [PMC free article] [PubMed] [Google Scholar]
  27. Theilade P., Hansen J. M., Skovsted L., Faber J., Kirkegård C., Friis T., Siersbaek-Nielsen K. Propranolol influences serum T3 and reverse T3 in hyperthyroidism. Lancet. 1977 Aug 13;2(8033):363–363. doi: 10.1016/s0140-6736(77)91532-x. [DOI] [PubMed] [Google Scholar]
  28. Turner P., Granville-Grossman K. L. Effect of adrenergic receptor blockade of the tachycardia of thyrotoxicosis and anxiety state. Lancet. 1965 Dec 25;2(7426):1316–1318. doi: 10.1016/s0140-6736(65)92340-8. [DOI] [PubMed] [Google Scholar]
  29. Turner P., Hill R. C. A comparison of three beta-adrenergic receptor-blocking drugs in thyrotoxic tachycardia. J Clin Pharmacol J New Drugs. 1968 Jul-Aug;8(4):268–271. doi: 10.1002/j.1552-4604.1968.tb00104.x. [DOI] [PubMed] [Google Scholar]
  30. Verhoeven R. P., Visser T. J., Doctor R., Hennemann G., Schalekamp M. A. Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. J Clin Endocrinol Metab. 1977 May;44(5):1002–1005. doi: 10.1210/jcem-44-5-1002. [DOI] [PubMed] [Google Scholar]
  31. Wiersinga W. M., Touber J. L. The influence of beta-adrenoceptor blocking agents on plasma thyroxine and triiodothyronine. J Clin Endocrinol Metab. 1977 Aug;45(2):293–298. doi: 10.1210/jcem-45-2-293. [DOI] [PubMed] [Google Scholar]
  32. Williams E. S., Jacobs H. S. Effect of propranolol on serum-thyroxine. Lancet. 1970 Oct 17;2(7677):829–830. doi: 10.1016/s0140-6736(70)91501-1. [DOI] [PubMed] [Google Scholar]
  33. Young R. R., Growdon J. H., Shahani B. T. Beta-adrenergic mechanisms in action tremor. N Engl J Med. 1975 Nov 6;293(19):950–953. doi: 10.1056/NEJM197511062931902. [DOI] [PubMed] [Google Scholar]

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