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. 1980 May;9(5):493–498. doi: 10.1111/j.1365-2125.1980.tb05845.x

Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

A G Leitch, J M Hopkin, D A Ellis, D M Clarkson, S Merchant, G J McHardy
PMCID: PMC1429963  PMID: 6772199

Abstract

Neither propranolol (80 mg) nor metoprolol (100 mg) give orally to eight normal subjects altered mean ventilatory responses to carbon dioxide or to moderate graded exercise. Incremental doses of the drugs to totals of 320 mg propranolol and 400 mg metoprolol also did not effect these ventilatory responses. Both drugs markedly decreased the heart rate response to exercise. Neither propranolol nor metoprolol are likely to cause CO2 retention by an effect on the ventilatory responses to inhaled carbon dioxide or to exercise.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown H. V., Wasserman K., Whipp B. J. Effect of beta-adrenergic blockade during exercise on ventilation and gas exchange. J Appl Physiol. 1976 Dec;41(6):886–892. doi: 10.1152/jappl.1976.41.6.886. [DOI] [PubMed] [Google Scholar]
  2. CUNNINGHAM D. J., HEY E. N., PATRICK J. M., LLOYD B. B. The effect of noradrenaline infusion on the relation between pulmonary ventilation and the alveolar PO2 and PCO2 in man. Ann N Y Acad Sci. 1963 Jun 24;109:756–771. doi: 10.1111/j.1749-6632.1963.tb13504.x. [DOI] [PubMed] [Google Scholar]
  3. CUNNINGHAM D. J., SHAW D. G., LAHIRI S., LLOYD B. B. The effect of maintained ammonium chloride acidosis on the relation between pulmonary ventilation and alveolar oxygen and carbon dioxide in man. Q J Exp Physiol Cogn Med Sci. 1961 Oct;46:323–334. doi: 10.1113/expphysiol.1961.sp001550. [DOI] [PubMed] [Google Scholar]
  4. Ervik M. Quantitative determination of metoprolol in plasma and urine by gas chromatography. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):136–144. doi: 10.1111/j.1600-0773.1975.tb03330.x. [DOI] [PubMed] [Google Scholar]
  5. Freedman S., Prowse K. How many blows make an F.E.V.1.0? Lancet. 1966 Sep 17;2(7464):618–619. doi: 10.1016/s0140-6736(66)91928-3. [DOI] [PubMed] [Google Scholar]
  6. Gayrard P., Orehek J., Grimaud C., Charpin J. Beta-adrenergic function in airways of healthy and asthmatic subjects. Thorax. 1975 Dec;30(6):657–662. doi: 10.1136/thx.30.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heistad D. D., Wheeler R. C., Mark A. L., Schmid P. G., Abboud F. M. Effects of adrenergic stimulation on ventilation in man. J Clin Invest. 1972 Jun;51(6):1469–1475. doi: 10.1172/JCI106943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirshman C. A., McCullough R. E., Weil J. V. Normal values for hypoxic and hypercapnic ventilaroty drives in man. J Appl Physiol. 1975 Jun;38(6):1095–1098. doi: 10.1152/jappl.1975.38.6.1095. [DOI] [PubMed] [Google Scholar]
  9. Joels N., White H. The contribution of the arterial chemoreceptors to the stimulation of respiration by adrenaline and noradrenaline in the cat. J Physiol. 1968 Jul;197(1):1–23. doi: 10.1113/jphysiol.1968.sp008541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Leitch A. G., Clancy L. J., Costello J. F., Flenley D. C. Effect of intravenous infusion of salbutamol on ventilatory response to carbon dioxide and hypoxia and on heart rate and plasma potassium in normal men. Br Med J. 1976 Feb 14;1(6006):365–367. doi: 10.1136/bmj.1.6006.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McGavin C. R., Williams I. P. The effects of oral propranolol and metoprolol on lung function and exercise performance in chronic airways obstruction. Br J Dis Chest. 1978 Oct;72(4):327–332. [PubMed] [Google Scholar]
  12. Mustchin C. P., Gribbin H. R., Tattersfield A. E., George C. F. Reduced respiratory responses to carbon dioxide after propranolol: a central action. Br Med J. 1976 Nov 20;2(6046):1229–1231. doi: 10.1136/bmj.2.6046.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Patrick J. M., Pearson S. B. Propranolol and the ventilatory response to CO2 and hypoxia in man [proceedings]. J Physiol. 1978 Mar;276:68P–69P. [PubMed] [Google Scholar]
  14. Read D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1967 Feb;16(1):20–32. doi: 10.1111/imj.1967.16.1.20. [DOI] [PubMed] [Google Scholar]
  15. Reybrouck T., Amery A., Billiet L. Hemodynamic response to graded exercise after chronic beta-adrenergic blockade. J Appl Physiol Respir Environ Exerc Physiol. 1977 Feb;42(2):133–138. doi: 10.1152/jappl.1977.42.2.133. [DOI] [PubMed] [Google Scholar]
  16. Skinner C., Gaddie J., Palmer K. N. Comparison of effects of metoprolol and propranolol on asthmatic airway obstruction. Br Med J. 1976 Feb 28;1(6008):504–504. doi: 10.1136/bmj.1.6008.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Spiro S. G., Juniper E., Bowman P., Edwards R. H. An increasing work rate test for assessing the physiological strain of submaximal exercise. Clin Sci Mol Med. 1974 Feb;46(2):191–206. doi: 10.1042/cs0460191. [DOI] [PubMed] [Google Scholar]
  18. Wasserman K. Breathing during exercise. N Engl J Med. 1978 Apr 6;298(14):780–785. doi: 10.1056/NEJM197804062981408. [DOI] [PubMed] [Google Scholar]

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