Abstract
1 Plasma theophylline concentrations following administration of sustained-release (SR) theophylline tablets were determined in ten healthy volunteers using a dose of 190 mg or 380 mg 12 hourly. 2 The plasma theophylline levels during the first 12 h period confirmed the sustained-release formulation characteristics, with the plasma drug concentrations reaching a plateau for the last 6 hours. 3 During the fifth 12 h dosing period the mean maximum and minimum plasma theophylline concentrations were 7.25 and 4.30 microgram/ml after 190 mg SR theophylline 12 hourly (n = 6) and 12.96 and 7.36 microgram/ml after 380 mg 12 hourly (n = 5), although there was marked between-subject variation in plasma theophylline concentrations. 4 One subject withdrew from the study due to side effects, which were more common when the higher dose of SR theophylline was given.
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Selected References
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- Boroda C., Miller R. B., Leslie S. T., Nicol E. G., Thomson I. Comparison of the bioavailability of aminophylline in a conventional base and in a continous-release base. J Clin Pharmacol. 1973 Oct;13(10):383–387. doi: 10.1002/j.1552-4604.1973.tb00183.x. [DOI] [PubMed] [Google Scholar]
- Dusci L. J., Hackett L. P., McDonald I. A. Gas-liquid chromatographic determination of theophylline in human plasma. J Chromatogr. 1975 Jan 29;104(1):147–150. doi: 10.1016/s0021-9673(01)85498-4. [DOI] [PubMed] [Google Scholar]
- Hendeles L., Weinberger M., Wyatt R. Guide to oral theophylline therapy for the treatment of chronic asthma. Am J Dis Child. 1978 Sep;132(9):876–880. [PubMed] [Google Scholar]
- Hunt S. N., Jusko W. J., Yurchak A. M. Effect of smoking on theophylline disposition. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):546–551. doi: 10.1002/cpt1976195part1546. [DOI] [PubMed] [Google Scholar]
- Jenne J. W., Wyze M. S., Rood F. S., MacDonald F. M. Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline. Clin Pharmacol Ther. 1972 May-Jun;13(3):349–360. doi: 10.1002/cpt1972133349. [DOI] [PubMed] [Google Scholar]
- Mitenko P. A., Ogilvie R. I. Rational intravenous doses of theophylline. N Engl J Med. 1973 Sep 20;289(12):600–603. doi: 10.1056/NEJM197309202891202. [DOI] [PubMed] [Google Scholar]
- Nicholson D. P., Chick T. W. A re-evaluation of parenteral aminophylline. Am Rev Respir Dis. 1973 Aug;108(2):241–247. doi: 10.1164/arrd.1973.108.2.241. [DOI] [PubMed] [Google Scholar]
- Powell J. R., Thiercelin J. F., Vozeh S., Sansom L., Riegelman S. The influence of cigarette smoking and sex on theophylline disposition. Am Rev Respir Dis. 1977 Jul;116(1):17–23. doi: 10.1164/arrd.1977.116.1.17. [DOI] [PubMed] [Google Scholar]
- Weinberger M., Hendeles L., Bighley L. The relation of product formulation to absorption of oral theophylline. N Engl J Med. 1978 Oct 19;299(16):852–857. doi: 10.1056/NEJM197810192991603. [DOI] [PubMed] [Google Scholar]