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. 1980 Apr;9(4):327–331. doi: 10.1111/j.1365-2125.1980.tb01058.x

Induction of delta-aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy--comparison with changes in rat hepatic tissue.

K E McColl, M R Moore, G G Thompson, A Goldberg
PMCID: PMC1429979  PMID: 7378249

Abstract

1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta-aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem-requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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