Abstract
1 The pharmacological actions of piretanide, a new high efficiency diuretic, were studied in sixteen patients with GFR (inulin clearance) varying from 0.1--2.5 ml/s. 2 After hydration and following two control periods, a single dose of 6 mg piretanide was ingested. Thereafter, urine was collected every 30 min for 2 h and every hour for the next 4 h. Fluid losses were replaced. 3 The following measurements were made: urine flow rate, clearances of inulin, PAH, urea, creatinine, uric acid, osmolar and free water clearances, excretion rates of sodium, chloride, potassium, calcium, phosphate, bicarbonate, ammonium, titratable acidity and urine pH. 4 Main results showed piretanide was efficient in the group with normal GFR (inulin clearance greater than 1.5 ml/s) and in the group with slightly decreased GFR (1.0 less than inulin clearance less than 1.4 ml/s), in terms of diuresis, natriuresis, kaliuresis and calciuresis. It was inefficient in the group with severe renal insufficiency (inulin clearance less than 0.3 ml/s). 5 Free water clearance showed preservation of diluting ability to a large extent. 6 In the three groups, no significant change in inulin clearance and PAH clearance occurred.
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- CARAWAY W. T. Determination of uric acid in serum by a carbonate method. Am J Clin Pathol. 1955 Jul;25(7):840–845. doi: 10.1093/ajcp/25.7_ts.0840. [DOI] [PubMed] [Google Scholar]
- Kraml M. A semi-automated determination of phospholipids. Clin Chim Acta. 1966 Apr;13(4):442–448. doi: 10.1016/0009-8981(66)90235-x. [DOI] [PubMed] [Google Scholar]
- Lawrence J. R., Ansari A. F., Elliott H. L., Sumner D. J., Brunton G. F., Whiting B., Whitesmith R. Kinetic and dynamic comparison of piretanide and furosemide. Clin Pharmacol Ther. 1978 May;23(5):558–565. doi: 10.1002/cpt1978235558. [DOI] [PubMed] [Google Scholar]
- Roberts C. J., Homeida M., Roberts F., Bogie W. Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects. Br J Clin Pharmacol. 1978 Aug;6(2):129–133. doi: 10.1111/j.1365-2125.1978.tb00837.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stason W. B., Cannon P. J., Heinemann H. O., Laragh J. H. Furosemide. A clinical evaluation of its diuretic action. Circulation. 1966 Nov;34(5):910–920. doi: 10.1161/01.cir.34.5.910. [DOI] [PubMed] [Google Scholar]
- Stein J. H., Wilson C. B., Kirkendall W. M. Differences in the acute effects of furosemide and ethacrynic acid in man. J Lab Clin Med. 1968 Apr;71(4):654–665. [PubMed] [Google Scholar]