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. 1980 Jun;9(6):537–546. doi: 10.1111/j.1365-2125.1980.tb01078.x

Lung mucus production and mucociliary clearance: methods of assessment.

S W Clarke, D Pavia
PMCID: PMC1430013  PMID: 6992821

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed T., Januszkiewicz A. J., Landa J. F., Brown A., Chapman G. A., Kenny P. J., Finn R. D., Bondick J., Sackner M. A. Effect of local radioactivity on trachael mucous velocity of sheep. Am Rev Respir Dis. 1979 Sep;120(3):567–575. doi: 10.1164/arrd.1979.120.3.567. [DOI] [PubMed] [Google Scholar]
  2. Albert R. E., Lippmann M., Briscoe W. The characteristics of bronchial clearance in humans and the effects of cigarette smoking. Arch Environ Health. 1969 May;18(5):738–755. doi: 10.1080/00039896.1969.10665482. [DOI] [PubMed] [Google Scholar]
  3. Albert R. E., Lippmann M., Peterson H. T., Jr, Berger J., Sanborn K., Bohning D. Bronchial deposition and clearance of aerosols. Arch Intern Med. 1973 Jan;131(1):115–127. [PubMed] [Google Scholar]
  4. Asmundsson T., Kilburn K. H. Mucociliary clearance rates at various levels in dog lungs. Am Rev Respir Dis. 1970 Sep;102(3):388–397. doi: 10.1164/arrd.1970.102.3.388. [DOI] [PubMed] [Google Scholar]
  5. Barnett B., Miller C. E. Flow induced by biological mucociliary systems. Ann N Y Acad Sci. 1966 Sep 30;130(3):891–901. doi: 10.1111/j.1749-6632.1966.tb12633.x. [DOI] [PubMed] [Google Scholar]
  6. Bateman J. R., Clarke S. W., Pavia D., Sheahan N. F. Reduction in clearance of secretions from the human lung during sleep [proceedings]. J Physiol. 1978 Nov;284:55P–55P. [PubMed] [Google Scholar]
  7. Bateman J. R., Newman S. P., Daunt K. M., Pavia D., Clarke S. W. Regional lung clearance of excessive bronchial secretions during chest physiotherapy in patients with stable chronic airways obstruction. Lancet. 1979 Feb 10;1(8111):294–297. doi: 10.1016/s0140-6736(79)90705-0. [DOI] [PubMed] [Google Scholar]
  8. Bateman J. R., Pavia D., Clarke S. W. The retention of lung secretions during the night in normal subjects. Clin Sci Mol Med Suppl. 1978 Dec;55(6):523–527. doi: 10.1042/cs0550523. [DOI] [PubMed] [Google Scholar]
  9. Bertrand A., Puchelle E. Mesure de la clearance muco-ciliaire des bronches proximales chez le bronchitique chronique. Pathol Biol (Paris) 1977 Nov;25(9):623–627. [PubMed] [Google Scholar]
  10. Booker D. V., Chamberlain A. C., Rundo J., Muir D. C., Thomson M. L. Elimination of 5 mu particles from the human lung. Nature. 1967 Jul 1;215(5096):30–33. doi: 10.1038/215030a0. [DOI] [PubMed] [Google Scholar]
  11. Cammer P., Strandberg K., Philipson K. Increased mucociliary transport by cholinergic stimulation. Arch Environ Health. 1974 Oct;29(4):220–224. doi: 10.1080/00039896.1974.10666572. [DOI] [PubMed] [Google Scholar]
  12. Camner P., Jarstrand C., Philipson K. Tracheobronchial clearance in patients with influenza. Am Rev Respir Dis. 1973 Jul;108(1):131–135. doi: 10.1164/arrd.1973.108.1.131. [DOI] [PubMed] [Google Scholar]
  13. Camner P., Mossberg B., Philipson K., Strandberg K. Elimination of test particles from the human tracheobronchial tract by voluntary coughing. Scand J Respir Dis. 1979 Apr;60(2):56–62. [PubMed] [Google Scholar]
  14. Camner P., Philipson K., Arvidsson T. Cigarette smoking in man. Short-term effect on mucociliary transport. Arch Environ Health. 1971 Dec;23(6):421–426. doi: 10.1080/00039896.1971.10666030. [DOI] [PubMed] [Google Scholar]
  15. Camner P., Philipson K. Human alveolar deposition of 4 micron teflon particles. Arch Environ Health. 1978 Jul-Aug;33(4):181–185. doi: 10.1080/00039896.1978.10667331. [DOI] [PubMed] [Google Scholar]
  16. Clarke S. W., Jones J. G., Oliver D. R. Resistance to two-phase gas-liquid flow in airways. J Appl Physiol. 1970 Oct;29(4):464–471. doi: 10.1152/jappl.1970.29.4.464. [DOI] [PubMed] [Google Scholar]
  17. DENTON R. Bronchial obstruction in cystic fibrosis: rheological factors. Pediatrics. 1960 Apr;25:611–620. [PubMed] [Google Scholar]
  18. Dawson H., Douglas R. B., Pavia D., Reeves E., Short M. D., Thomson M. L. An inexpensive automatic two-detector lung scanner. Phys Med Biol. 1971 Oct;16(4):691–692. doi: 10.1088/0031-9155/16/4/013. [DOI] [PubMed] [Google Scholar]
  19. Dolovich M. B., Sanchis J., Rossman C., Newhouse M. T. Aerosol penetrance: a sensitive index of peripheral airways obstruction. J Appl Physiol. 1976 Mar;40(3):468–471. doi: 10.1152/jappl.1976.40.3.468. [DOI] [PubMed] [Google Scholar]
  20. Dulfano M. J., Adler K. B. Physical properties of sputum. VII. Rheologic properties and mucociliary transport. Am Rev Respir Dis. 1975 Sep;112(3):341–347. doi: 10.1164/arrd.1975.112.3.341. [DOI] [PubMed] [Google Scholar]
  21. Eliasson R., Mossberg B., Camner P., Afzelius B. A. The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med. 1977 Jul 7;297(1):1–6. doi: 10.1056/NEJM197707072970101. [DOI] [PubMed] [Google Scholar]
  22. Foster W. M., Bergofsky E. H., Bohning D. E., Lippmann M., Albert R. E. Effect of adrenergic agents and their mode of action on mucociliary clearance in man. J Appl Physiol. 1976 Aug;41(2):146–152. doi: 10.1152/jappl.1976.41.2.146. [DOI] [PubMed] [Google Scholar]
  23. Friedman M., Dougherty R., Nelson S. R., White R. P., Sackner M. A., Wanner A. Acute effects of an aerosol hair spray on tracheal mucociliary transport. Am Rev Respir Dis. 1977 Aug;116(2):281–286. doi: 10.1164/arrd.1977.116.2.281. [DOI] [PubMed] [Google Scholar]
  24. Gamsu G., Singer M. M., Vincent H. H., Berry S., Nadel J. A. Postoperative impairment of mucous transport in the lung. Am Rev Respir Dis. 1976 Oct;114(4):673–679. doi: 10.1164/arrd.1976.114.4.673. [DOI] [PubMed] [Google Scholar]
  25. Gamsu G., Weintraub R. M., Nadel J. A. Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method. Am Rev Respir Dis. 1973 Feb;107(2):214–224. doi: 10.1164/arrd.1973.107.2.214. [DOI] [PubMed] [Google Scholar]
  26. Goldberg I. S., Lourenço R. V. Deposition of aerosols in pulmonary disease. Arch Intern Med. 1973 Jan;131(1):88–91. [PubMed] [Google Scholar]
  27. Goodman R. M., Yergin B. M., Landa J. F., Golivanux M. H., Sackner M. A. Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis. Am Rev Respir Dis. 1978 Feb;117(2):205–214. doi: 10.1164/arrd.1978.117.2.205. [DOI] [PubMed] [Google Scholar]
  28. Green G. M. Alveolobronchiolar transport mechanisms. Arch Intern Med. 1973 Jan;131(1):109–114. [PubMed] [Google Scholar]
  29. Haslam P. L., Turton C. W., Heard B., Lukoszek A., Collins J. V., Salsbury A. J., Turner-Warwick M. Bronchoalveolar lavage in pulmonary fibrosis: comparison of cells obtained with lung biopsy and clinical features. Thorax. 1980 Jan;35(1):9–18. doi: 10.1136/thx.35.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Hendry W. F., Knight R. K., Whitfield H. N., Stansfeld A. G., Pryse-Davies J., Ryder T. A., Pavia D., Bateman J. R., Clarke S. W. Obstructive azoospermia: respiratory function tests, electron microscopy and the results of surgery. Br J Urol. 1978 Dec;50(7):598–604. doi: 10.1111/j.1464-410x.1978.tb06221.x. [DOI] [PubMed] [Google Scholar]
  31. Iravani J., As van A. Mucus transport in the tracheobronchial tree of normal and bronchitic rats. J Pathol. 1972 Feb;106(2):81–93. doi: 10.1002/path.1711060204. [DOI] [PubMed] [Google Scholar]
  32. Jarstrand C., Camner P., Philipson K. Mycoplasma pneumoniae and tracheobronchial clearance. Am Rev Respir Dis. 1974 Oct;110(4):415–419. doi: 10.1164/arrd.1974.110.4.415. [DOI] [PubMed] [Google Scholar]
  33. Jones J. G., Clarke S. W. Dynamics of cough. Br J Anaesth. 1970 Apr;42(4):280–285. doi: 10.1093/bja/42.4.280. [DOI] [PubMed] [Google Scholar]
  34. Kilburn K. H. Cilia and mucus transport as determinants of the response of lung to air pollutants. Arch Environ Health. 1967 Jan;14(1):77–91. doi: 10.1080/00039896.1967.10664699. [DOI] [PubMed] [Google Scholar]
  35. Leith D. E. Cough. Phys Ther. 1968 May;48(5):439–447. doi: 10.1093/ptj/48.5.439. [DOI] [PubMed] [Google Scholar]
  36. Lichtiger M., Landa J. F., Hirsch J. A. Velocity of tracheal mucus in anesthetized women undergoing gynecologic surgery. Anesthesiology. 1975 Jun;42(6):753–756. doi: 10.1097/00000542-197506000-00024. [DOI] [PubMed] [Google Scholar]
  37. Lippmann M., Albert R. E. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J. 1969 May-Jun;30(3):257–275. doi: 10.1080/00028896909343120. [DOI] [PubMed] [Google Scholar]
  38. Lourenço R. V., Klimek M. F., Borowski C. J. Deposition and clearance of 2 micron particles in the tracheobronchial tree of normal subjects--smokers and nonsmokers. J Clin Invest. 1971 Jul;50(7):1411–1420. doi: 10.1172/JCI106624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Lourenço R. V., Loddenkemper R., Carton R. W. Patterns of distribution and clearance of aerosols in patients with bronchiectasis. Am Rev Respir Dis. 1972 Dec;106(6):857–866. doi: 10.1164/arrd.1972.106.6.857. [DOI] [PubMed] [Google Scholar]
  40. Medici T. C., Chodosh S., Ishikawa S., Enslein K. Physical properties of sputum and respiratory function in chronic bronchial disease. Bull Physiopathol Respir (Nancy) 1973 Mar-Apr;9(2):315–324. [PubMed] [Google Scholar]
  41. Mezey R. J., Cohn M. A., Fernandez R. J., Januszkiewicz A. J., Wanner A. Mucociliary transport in allergic patients with antigen-induced bronchospasm. Am Rev Respir Dis. 1978 Oct;118(4):677–684. doi: 10.1164/arrd.1978.118.4.677. [DOI] [PubMed] [Google Scholar]
  42. Morrow P. E. Alveolar clearance of aerosols. Arch Intern Med. 1973 Jan;131(1):101–108. [PubMed] [Google Scholar]
  43. Morrow P. E. Conference on the scientific basis of respiratory therapy. Aerosol therapy. Aerosol characterization and deposition. Am Rev Respir Dis. 1974 Dec;110(6 Pt 2):88–99. doi: 10.1164/arrd.1974.110.6P2.88. [DOI] [PubMed] [Google Scholar]
  44. Mossberg B., Strandberg K., Philipson K., Camner P. Tracheobronchial clearance and beta-adrenoceptor stimulation in patients with chronic bronchitis. Scand J Respir Dis. 1976;57(6):281–289. [PubMed] [Google Scholar]
  45. Nadel J. A., Davis B., Phipps R. J. Control of mucus secretion and ion transport in airways. Annu Rev Physiol. 1979;41:369–381. doi: 10.1146/annurev.ph.41.030179.002101. [DOI] [PubMed] [Google Scholar]
  46. Pavia D., Bateman J. R., Sheahan N. F., Clarke S. W. Effect of ipratropium bromide on mucociliary clearance and pulmonary function in reversible airways obstruction. Thorax. 1979 Aug;34(4):501–507. doi: 10.1136/thx.34.4.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Pavia D., Short M. D., Thomson M. L. No demonstrable long term effects of cigarette smoking on the mucociliary mechanism of the human lung. Nature. 1970 Jun 27;226(5252):1228–1231. doi: 10.1038/2261228a0. [DOI] [PubMed] [Google Scholar]
  48. Pavia D., Thomson M. L., Clarke S. W. Enhanced clearance of secretions from the human lung after the administration of hypertonic saline aerosol. Am Rev Respir Dis. 1978 Feb;117(2):199–203. doi: 10.1164/arrd.1978.117.2.199. [DOI] [PubMed] [Google Scholar]
  49. Pavia D., Thomson M. L. Inhibition of mucociliary clearance from the human lung by hyoscine. Lancet. 1971 Feb 27;1(7696):449–450. doi: 10.1016/s0140-6736(71)92432-9. [DOI] [PubMed] [Google Scholar]
  50. Pavia D., Thomson M. L., Pocock S. J. Evidence for temporary slowing of mucociliary clearance in the lung caused by tobacco smoking. Nature. 1971 Jun 4;231(5301):325–326. doi: 10.1038/231325a0. [DOI] [PubMed] [Google Scholar]
  51. Pavia D., Thomson M. L. The fractional deposition of inhaled 2 and 5 mum particles in the alveolar and tracheobronchial regions of the healthy human lung. Ann Occup Hyg. 1976 Nov;19(2):109–114. doi: 10.1093/annhyg/19.2.109. [DOI] [PubMed] [Google Scholar]
  52. Pavia D., Thomson M., Shannon H. S. Aerosol inhalation and depth of deposition in the human lung. The effect of airway obstruction and tidal volume inhaled. Arch Environ Health. 1977 May-Jun;32(3):131–137. doi: 10.1080/00039896.1977.10667269. [DOI] [PubMed] [Google Scholar]
  53. REID L. Chronic bronchitis and hypersecretion of mucus. Lect Sci Basis Med. 1958 1959;8:235–255. [PubMed] [Google Scholar]
  54. Richardson P. S., Phipps R. J. The anatomy, physiology, pharmacology and pathology of tracheobronchial mucus secretion and the use of expectorant drugs in human disease. Pharmacol Ther B. 1978;3(4):441–479. doi: 10.1016/s0306-039x(78)90010-7. [DOI] [PubMed] [Google Scholar]
  55. Ruffin R. E., Wolff R. K., Dolovich M. B., Rossman C. M., Fitzgerald J. D., Newhouse M. T. Aerosol therapy with Sch 1000. Short-term mucociliary clearance in normal and bronchitic subjects and toxicology in normal subjects. Chest. 1978 Apr;73(4):501–506. doi: 10.1378/chest.73.4.501. [DOI] [PubMed] [Google Scholar]
  56. Sackner M. A., Landa J., Hirsch J., Zapata A. Pulmonary effects of oxygen breathing. A 6-hour study in normal men. Ann Intern Med. 1975 Jan;82(1):40–43. doi: 10.7326/0003-4819-82-1-40. [DOI] [PubMed] [Google Scholar]
  57. Sackner M. A., Rosen M. J., Wanner A. Estimation of tracheal mucous velocity by bronchofiberscopy. J Appl Physiol. 1973 Apr;34(4):495–499. doi: 10.1152/jappl.1973.34.4.495. [DOI] [PubMed] [Google Scholar]
  58. Sanchis J., Dolovich M., Chalmers R., Newhouse M. Quantitation of regional aerosol clearance in the normal human lung. J Appl Physiol. 1972 Dec;33(6):757–762. doi: 10.1152/jappl.1972.33.6.757. [DOI] [PubMed] [Google Scholar]
  59. Sanchis J., Dolovich M., Rossman C., Wilson W., Newhouse M. Pulmonary mucociliary clearance in cystic fibrosis. N Engl J Med. 1973 Mar 29;288(13):651–654. doi: 10.1056/NEJM197303292881304. [DOI] [PubMed] [Google Scholar]
  60. Serafini S. M., Wanner A., Michaelson E. D. Mucociliary transport in central and intermediate size airways: effect of aminophyllin. Bull Eur Physiopathol Respir. 1976 May-Jun;12(3):415–422. [PubMed] [Google Scholar]
  61. TOIGO A., IMARISIO J. J., MURMALL H., LEPPER M. N. Clearance of large carbon particles from the human tracheobronchial tree. Am Rev Respir Dis. 1963 Apr;87:487–492. doi: 10.1164/arrd.1963.87.4.487. [DOI] [PubMed] [Google Scholar]
  62. TOREMALM N. G. The daily amoung of tracheo-bronchial secretions in man. A method for continuous tracheal aspiration in laryngectomized and tracheotomized patients. Acta Otolaryngol Suppl. 1960;158:43–53. doi: 10.3109/00016486009122392. [DOI] [PubMed] [Google Scholar]
  63. Thomson M. L., Pavia D., Gregg I., Stark J. E. Bromhexine and mucociliary clearance in chronic bronchitis. Br J Dis Chest. 1974 Jan;68(1):21–27. [PubMed] [Google Scholar]
  64. Thomson M. L., Pavia D., Jones C. J., McQuiston T. A. No demonstrable effect of S-carboxymethylcysteine on clearance of secretions from the human lung. Thorax. 1975 Dec;30(6):669–673. doi: 10.1136/thx.30.6.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Thomson M. L., Pavia D. Long-term tobacco smoking and mucociliary clearance from the human lung in health and respiratory impairment. Arch Environ Health. 1973 Feb;26(2):86–89. doi: 10.1080/00039896.1973.10666230. [DOI] [PubMed] [Google Scholar]
  66. Thomson M. L., Pavia D. Particle penetration and clearance in the human lung. Results in healthy subjects and subjects with chronic bronchitis. Arch Environ Health. 1974 Oct;29(4):214–219. doi: 10.1080/00039896.1974.10666571. [DOI] [PubMed] [Google Scholar]
  67. Thomson M. L., Short M. D. Mucociliary function in health, chronic obstructive airway disease, and asbestosis. J Appl Physiol. 1969 May;26(5):535–539. doi: 10.1152/jappl.1969.26.5.535. [DOI] [PubMed] [Google Scholar]
  68. Wanner A. The role of mucociliary dysfunction in bronchial asthma. Am J Med. 1979 Sep;67(3):477–485. doi: 10.1016/0002-9343(79)90797-6. [DOI] [PubMed] [Google Scholar]
  69. Wolff R. K., Dolovich M. B., Obminski G., Newhouse M. T. Effects of exercise and eucapnic hyperventilation on bronchial clearance in man. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):46–50. doi: 10.1152/jappl.1977.43.1.46. [DOI] [PubMed] [Google Scholar]
  70. Wong J. W., Keens T. G., Wannamaker E. M., Crozier D. N., Levison H., Aspin N. Effects of gravity on tracheal mucus transport rates in normal subjects and in patients with cystic fibrosis. Pediatrics. 1977 Aug;60(2):146–152. [PubMed] [Google Scholar]
  71. Wood R. E., Wanner A., Hirsch J., Farrell P. M. Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline. Am Rev Respir Dis. 1975 Jun;111(6):733–738. doi: 10.1164/arrd.1975.111.6.733. [DOI] [PubMed] [Google Scholar]
  72. Yeates D. B., Aspin N., Levison H., Jones M. T., Bryan A. C. Mucociliary tracheal transport rates in man. J Appl Physiol. 1975 Sep;39(3):487–495. doi: 10.1152/jappl.1975.39.3.487. [DOI] [PubMed] [Google Scholar]

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