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. 1980 Jul;10(1):51–59. doi: 10.1111/j.1365-2125.1980.tb00501.x

A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.

R Wilkinson, I M Stevens, M Pickering, V Robson, T Hawkins, D N Kerr, J D Harry
PMCID: PMC1430025  PMID: 6994760

Abstract

1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra-renal beta 2-adrenoceptors may be of importance in the regulation of renal function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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