Abstract
1 The antihypertensive effects and side-effects of guanfacine and clonidine were compared in a single-blind, cross-over study.
2 The study consisted of two active treatment periods of 6 weeks each, which were both preceded by a 2 weeks placebo period. Thirty ambulatory, hypertensive patients (blood pressure WHO severity grades I-II) were admitted to the study. The results are based on the 24 patients who completed the study.
3 The optimal daily dose of guanfacine was in over half of the patients 3-4 mg, and of clonidine correspondingly 0.3-0.45 mg. A similar and statistically significant decrease in blood pressure was achieved with both drugs.
4 The most common side-effects with both drugs were tiredness and dryness of the mouth.
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Selected References
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