Abstract
1 The effects of acute and long-term treatment with guanfacine on ambulatory BP were studied.
2 The first day of therapy with guanfacine 1 mg produced a small reduction in BP whereas chronic therapy with doses up to 6gm given once daily produced a substantial smooth reduction throughout the whole 24 hours.
3 There were no noticeable symptoms or rebound effects on withdrawal of the drug; side-effects, were, however, prominent during therapy.
4 The drug reduced BP during dynamic exercise but did little during isometric exercise; no postural hypotension was noted during tilting.
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Selected References
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