Abstract
1 The haemodynamic mechanisms underlying the antihypertensive effect of guanfacine during chronic oral administration were studied.
2 Ten patients with essential hypertension were submitted to haemodynamic measurements at rest and during exercise, before and after 12 weeks' treatment with guanfacine alone at a daily dose of between 3 and 15 mg orally.
3 The relevant haemodynamic values were obtained by means of an arterial catheter in the aorta, a venous catheter in the right atrium, and the measurement of cardiac output using the thermodilution method.
4 The antihypertensive efficacy of guanfacine was confirmed.
5 In the seven patients with a high peripheral resistance the main effect of guanfacine was a marked decrease in total peripheral resistance. In three patients with hypertension characterized by high stroke volume and cardiac output, the main effect of guanfacine was to reduce these variables.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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