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. 1980;10(Suppl 1):71S–80S. doi: 10.1111/j.1365-2125.1980.tb04909.x

Differences in psychic performance with guanfacine and clonidine in normotensive subjects

J Kugler, R Seus, R Krauskopf, H M Brecht, A Raschig
PMCID: PMC1430114  PMID: 6994783

Abstract

1 Doses of clonidine 0.15 mg or guanfacine 1.0 mg, respectively, and 2 h later additional doses of clonidine 0.3 mg or guanfacine 2.0 mg, respectively, were given to 24 healthy students.

2 Blood pressure was reduced by the same amount by both drugs.

3 Plasma noradrenaline concentrations decreased with both drugs, but the reduction was significantly greater following the administration of clonidine.

4 Mental activity in the EEG was less suppressed in the guanfacine group than in the clonidine group. The differences were statistically significant.

5 Self-estimations for well-being and mood showed only small changes due to guanfacine but significant changes due to clonidine.

6 The decrease of information processing and the increase in reaction time, measured by performance in different psychometric tests, were significantly more pronounced after clonidine treatment than guanfacine.

7 A dose-response relationship could only be observed in vigilosomnograms, in the tests of self-estimation related to well-being and mood and in the decrease in plasma noradrenaline in the clonidine group.

8 It was concluded that guanfacine had a lesser CNS depressant action than clonidine, when administered in equipotent hypotensive doses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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