Abstract
1 In 20 patients suffering from mild hypertension (WHO classification I-II) the effect on vigilance was studied under double-blind conditions. Ten patients were given guanfacine 2 mg daily and ten others a placebo preparation.
2 Before the study and following 2 weeks' medication a battery of tests was applied in which the reaction time and attention were subjected to comparative analysis. The variation in blood pressure and heart rate under mental stress conditions was also tested.
3 The study shows a non-significant reduction in blood pressure in the guanfacine group without the parameters of vigilance being affected. Under mental stress, there was no impairment of haemodynamic reactions.
4 It is concluded that guanfacine, at the selected dose of 2 mg daily, has no apparent effect on the vigilance of hypertensive patients.
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Selected References
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- Bayliss P. F., Duncan S. M. The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function. Br J Clin Pharmacol. 1975 Dec;2(6):527–531. doi: 10.1111/j.1365-2125.1975.tb00571.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benton A. L. Interactive effects of age and brain disease on reaction time. Arch Neurol. 1977 Jun;34(6):369–370. doi: 10.1001/archneur.1977.00500180063013. [DOI] [PubMed] [Google Scholar]
- Heidbreder E., Pagel G., Röckel A., Heidland A. Beta-adrenergic blockade in stress protection. Limited effect of metoprolol in psychological stress reaction. Eur J Clin Pharmacol. 1978 Dec 18;14(6):391–398. doi: 10.1007/BF00716379. [DOI] [PubMed] [Google Scholar]
- Kleinlogel H., Scholtysik G., Sayers A. C. Effects of clonidine and BS 100-141 on the EEG sleep pattern in rats. Eur J Pharmacol. 1975 Aug;33(1):159–163. doi: 10.1016/0014-2999(75)90151-x. [DOI] [PubMed] [Google Scholar]
- Putzeys M. R., Hoobler S. W. Comparison of clonidine and methyldopa on blood pressure and side effects in hypertensive patients. Am Heart J. 1972 Apr;83(4):464–468. doi: 10.1016/0002-8703(72)90036-1. [DOI] [PubMed] [Google Scholar]
- Saameli K., Scholtysik G., Waite R. Pharmacology of BS 100-141, a centrally acting antihypertensive drug. Clin Exp Pharmacol Physiol. 1975;Suppl 2:207–212. [PubMed] [Google Scholar]