Abstract
1 The acute action of an intravenous infusion (5 min) of guanfacine in doses of 0.01, 0.02 and 0.04 mg/kg on peripheral circulation was studied in five hypertensive patients and compared with a placebo in a randomized study. The observations were combined for 2 h after drug administration.
2 Two phases of drug action were seen during and immediately after the administration of guanfacine; a dose-dependent decrease in blood flow mainly of the forefoot but also in the calf was combined with an increase in systolic and diastolic blood pressures and a decrease in heart rate. Peripheral resistance was increased in this phase. Later, an increase in blood flow to the foot combined with a tendency towards a decrease in blood pressure were observed.
3 These preliminary results show that this second phase of action of guanfacine is dependent on the dose given.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bock K. D., Heimsoth V., Merguet P., Schönermark J. Klinische und klinisch-experimentelle Untersuchungen mit einer neuen blutdrucksenkenden Substanz: Dichlorphenylaminoimidazolin. Dtsch Med Wochenschr. 1966 Oct 7;91(40):1761–1770. doi: 10.1055/s-0028-1111588. [DOI] [PubMed] [Google Scholar]
- Ehringer H., Deutsch E. Zur Wirkung von Raubasin auf Venentonus und Venenkapazität des Unterschenkels. Z Kreislaufforsch. 1968 Nov;57(11):1099–1105. [PubMed] [Google Scholar]
- Ehringer H. Differenzierte simultane Durchblutungsmessung konsekutiver Extremitätensegmente (gleichseitiger Unterschenkel und Fuss) mit einem automatisch registrierenden Venenverschlussplethysmographen: Zur Frage der Okklusionstechnik. Z Kreislaufforsch. 1969 May;58(5):500–509. [PubMed] [Google Scholar]
- Grabner G., Michalek P., Pokorny D., Vormittag E. Klinische und experimentelle Untersuchungen mit der neuen blutdrucksenkenden Substanz 2-(2,6-Dichlorphenylamino)-2-imidazolin-hydrochlorid. Arzneimittelforschung. 1966 Sep;16(9):1174–1179. [PubMed] [Google Scholar]
- WOOD J. E., ECKSTEIN J. W. A tandem foream plethysmograph for study of acute responses of the peripheral veins of man: the effect of environmental and local temperature change, and the effect of pooling blood in the extremities. J Clin Invest. 1958 Jan;37(1):41–50. doi: 10.1172/JCI103583. [DOI] [PMC free article] [PubMed] [Google Scholar]