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. 1980;10(Suppl 2):237S–244S. doi: 10.1111/j.1365-2125.1980.tb01806.x

Peripheral analgesia

Mechanism of the analgesic action of aspirin-like drugs and opiate antagonists

S H Ferreira
PMCID: PMC1430169  PMID: 6254551

Abstract

1 Prostaglandins released by tissue injury sensitize nociceptors and produce hyperalgesia.

2 Aspirin-like drugs inhibit prostaglandins I2 and E2, synthesis, which explains their anti-algic effect.

3 The anti-algic effect of aspirin-like drugs in carrageenin-induced rat paw inflammation may involve a central component.

4 Prostaglandin E2-induced hyperalgesia, once established, is not relieved by systemically administered drugs.

5 Prostaglandin-induced hyperalgesia is possibly a cyclic adenosine, 3′,5′-monophosphate C2+ dependent process.

6 Morphine, enkephalins, opiate antagonists and cyclic guanosine 3′,5′-monophosphate have a peripheral analgesic effect in the prostaglandin hyperalgesia test.

7 Morphine may produce peripheral analgesia by inhibiting adenylatecyclase activity at the nociceptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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