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. 1980;10(Suppl 2):407S–410S. doi: 10.1111/j.1365-2125.1980.tb01831.x

Gastrointestinal toxicity of minor analgesics

J M Duggan
PMCID: PMC1430173  PMID: 7002193

Abstract

1 The evidence for the risk of gastric erosions from aspirin is fragmentary.

2 Occult gastric bleeding following aspirin is poorly studied and the skewed distribution is unexplained; platelet factors may be relevant.

3 Overt gastric bleeding may follow aspirin; the risk is probably about one episode per two million doses.

4 There is epidemiological, clinical, experimental and histopathological evidence for an association between chronic aspirin use and chronic gastric ulcer.

5 An alternative to the Davenport hypothesis is proposed to explain the gastric action of aspirin and the non-steroidal anti-inflammatory agents.

6 Paracetamol is probably bland in its gastric actions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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